R-3327 MAT-LyLu cell line

This cell line is a valuable model for the studying prostate malignancies both in vitro and in vivo.

Contributors

Inventor Institute
John Isaacs Johns Hopkins University
Cat. #: 156410
Unit size: 1×10^6 cells / vial
Cancer types: Prostate cancer
Research Fields: Cancer;Drug development
Model: Cancer Model
Cancer Types In Detail: Prostate
Product description: This cell line was derived from the "H" subline and was passaged to the AT-1 subline of the parental R3327 tumor. The "H" subline is a heterogeneous cell line as it is comprised of androgen-dependent and androgen-independent tumor cells. Passing this heterogeneous tumor cell population in intact male rats allowed for the cloning of androgen-independent cell lines which gave rise to a fast-growing metastatic, anaplastic tumor (MAT) cell line which was further characterized to be highly metastatic to the lungs and the lymph nodes (MAT-LyLu). This cell line is a valuable model for the studying prostate malignancies both in vitro and in vivo.
Cellosaurus ID: CVCL_3848
Disease: Cancer
Format: Frozen
Shipping conditions: Dry ice
References:

Musialik et al. 2013. Oncol Rep. 29(5):1789-96. PMID: 23467722.

Isaacs et al. 1981. Invest Urol. 19(1):20-3. PMID: 7251319.

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