Cat. #153939
Fluorescent probe for Copper
Cat. #: 153939
Sub-type: Fluorescent Probe
Availability: Please enquire for quantities and pricing
Application: determination of Cu(I) binding affinities of proteins and small-molecule ligands
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Christoph J. Fahrni
Institute: Georgia Institute Of Technology
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Tool name: Fluorescent probe for Copper
- Research fields: Drug development;Other
- Tool sub type: Fluorescent Probe
- Description: Copper is an essential trace element that is central to a broad range of biological processes, including cellular respiration, connective tissue formation, pigment synthesis, antioxidant defense, and photosynthesis in plants and bacteria. The measurement of reliable Cu(I) protein binding affinities requires competing reference ligands with similar binding strengths; however, the literature on such reference ligands is not only sparse but often conflicting. Here, Dr. Farhrni has designed a water-solube fluorescence probe for the detection of aqueous Cu(I). This probe has a high selectivity (57-fold) for Cu(I) compared to other cations such as Cu(II), Hg(II), and Cd(II).
- Application: determination of Cu(I) binding affinities of proteins and small-molecule ligands
- Solubility: water
Application Details
- Application: determination of Cu(I) binding affinities of proteins and small-molecule ligands
References
- Morgan et al. 2013. Dalton Trans. 42(9):3240-8. PMID: 23169532.
- High-contrast fluorescence sensing of aqueous Cu(I) with triarylpyrazoline probes: dissecting the roles of ligand donor strength and excited state proton transfer.
