Germinal centres are sites within secondary lymph nodes where mature B lymphocytes proliferate, differentiate and mutate their antibody genes, enabling switching of their class of antibody during the course of infection.
| Inventor | Institute |
|---|---|
| Margaret Goodall | University of Birmingham |
| Cat. #: | 153234 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer;Cell biology;Immunology |
| Application: | IHC |
| Target: | CD97 ligand |
| Reactivity: | Human |
| Clone: | BU97 |
| Host: | Mouse |
| Class: | Monoclonal |
| Alternate name: | Complement decay-accelerating factor; CD55; Decay accelerating factor; DAF |
|---|---|
| Product description: | Macrophages are a type of white blood cell which through a process called phagocytosis engulfs and digests cellular debris, foreign substances, microbes, cancer cells. They can be found in all tissues where they play a critical role in the innate immune system and also help initiate adaptive immunity through recruiting lymphocytes and other immune cells. Germinal centres are sites within secondary lymph nodes where mature B lymphocytes proliferate, differentiate and mutate their antibody genes, enabling switching of their class of antibody during the course of infection. |
| Conjugation: | Unconjugated |
| Isotype: | IgG2b |
| Target background: | Macrophages are a type of white blood cell which through a process called phagocytosis engulfs and digests cellular debris, foreign substances, microbes, cancer cells. They can be found in all tissues where they play a critical role in the innate immune system and also help initiate adaptive immunity through recruiting lymphocytes and other immune cells. Germinal centres are sites within secondary lymph nodes where mature B lymphocytes proliferate, differentiate and mutate their antibody genes, enabling switching of their class of antibody during the course of infection. |
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| Format: | Liquid |
|---|---|
| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Leucocyte Typing VI, 1998, Kishimoto_T. Garland Publishing, NY. Ling et al. 1998. Clin Exp Immunol. 113(3):360-6. PMID: 9737663. Origin and properties of soluble CD21 (CR2) in human blood. Buescher et al. 1991. Public Health Rep. 106(3):333-8. PMID: 1905057. Problems in estimating the number of women in need of subsidized prenatal care. |
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