The paternally expressed Zdbf2 gene controls neonatal growth in mice, in a dose-sensitive but parent-of-origin-independent manner. We further found that Zdbf2-KO neonates failed to fully activate hypothalamic circuits that stimulate appetite, and suffered milk deprivation and diminished circulating Insulin Growth Factor 1 (IGF-1).
Official nomenclature:
C57BL6/Zdbf2embourc/Curie
CRISPR:
Yes
Production details:
Exon6 was removed using 2 flanking sgRNAs.
Cat. #:
162168
Research Fields:
Developmental biology
Zygosity:
Heterozygous
Strain:
C57BL6/J
Phenotype:
Growth retardation from birth with increased lethality. Phenotype is observed in homozygotes and in animals with paternal mutation only.
Primary citation:
Juliane Glaser et. al. 2022 eLife. Jan 20:11:e65641. PMID: 35049495
Shipping conditions:
Spermatoza- Dry Ice
References:
Juliane Glaser et. al. 2022 eLife. Jan 20:11:e65641. PMID: 35049495
Half dot plot- half violin plot showing the weight distribution in 2-week-old males (left) and females (right) of WT and Zdbf2-KO genotypes. Statistical analyses were performed by a two-tailed, unpaired, nonparametric Mann Whitney t test. ***p ≤ 0.001, **p ≤ 0.01.
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