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Patient Derived Xenografts (PDX) available now!
We have expanded our research tool offerings to include Patient–Derived Xenograft (PDX) models.
CancerTools.org now provide a large, diverse collection of:
- Breast cancer PDX models, deposited by Professor Alana Welm, from the University of Utah. This includes models of the most advanced and lethal forms of breast cancer, such as aggressive, metastatic and treatment-resistant subtypes.
- Non-small cell lung cancer (NSCLC) PDX models, deposited by Dr. Robert Hynds and Dr. David Pearce, from the Cancer Research UK (CRUK) Lung Cancer Centre of Excellence at University College London (UCL). These pioneering models have been derived from multiple regions of primary NSCLC tumours from patients enrolled in the Lung TRACERx study.
Read about our breast cancer PDX models
What are PDX models?
PDX models are generated by engrafting tumour tissues from patients into immunodeficient mice.
Image: Schematic illustrating the establishment of PDX models by grafting tumour tissues from a patient into immunodeficient mice, created with Biorender.
What are the key benefits of using PDX models?
- Highly valuable in recapitulating of patient tumour characteristics, including intratumour heterogeneity, genomic features, metastatic patterns, and drug responses.
- Highly translatable preclinical models that can be used to more accurately test therapy efficacy and predict patient drug responses than traditional models.
- Superior choice for studying advanced cancers than traditional models that fail to accurately recapitulate metastasis.
Explore our collection of breast cancer and TRACERx NSCLC PDX models:
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Breast cancer PDX models
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