ABHD5-flox mouse

Useful model for the generation of tissue/cell specific ABHD5-deficient mice. Animals might be useful for studies, e.g. on energy metabolism or skin barrier development/function.

Contributors

Inventor Institute
Franz Radner ; Rudolf Zechner University of Graz
SKU: 160869
Product description: Useful model for the generation of tissue/cell specific ABHD5-deficient mice. Animals might be useful for studies, e.g. on energy metabolism or skin barrier development/function.
Alternate name: ABHD5, CGI-58
Conditional: Yes
Conditional description: Conditional ready
Production details: A loxP site was inserted upstream of exon 4 and a floxed neomycin resistance cassette was inserted downstream of exon 7. Cre-mediated recombination removed the selection cassette and left Abhd5 exon 4 – 7 flanked by loxP sites. Further details are available upon request.
Cat. #: 160869
Research Fields: Developmental biology;Metabolism
Target: Abhydrolase domain containing 5, comparative gene identification-58, Chanarin-Dorfman, Ichthyosis
Model: Conditional KO
Zygosity: Homozygous
Strain: C57BL/6J
Phenotype: These mice are conditional ready, and phenotypical identical to C57BL/6J mice.
References:

23413028

Grond et al. 2017. J Invest Dermatol. 137(2):403-413. PMID: 27725204.

Jaeger et al. 2015. J Hepatol. 63(2):437-45. PMID: 25733154.

Radner et al. 2010. J Biol Chem. 285(10):7300-11. PMID: 20023287.

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