Disease model for psoriasis; in vivo study of human alpha3 and beta1 integrin transgene expression in skin.
| Inventor | Institute |
|---|---|
| Fiona Watt | Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| SKU: | 151549 |
|---|---|
| Product description: | Disease model for psoriasis; in vivo study of human alpha3 and beta1 integrin transgene expression in skin. |
| Conditional: | Yes |
| Conditional description: | Conditional expression of integrins under involucrin promoter giving tissue-specific suprabasal epidermal expression. |
| Production details: | Involucrin – integrin transgene expression constructs were injected into fertilized oocytes from F1 hybrid CBAxC57Bl/6 mice. Transgene-positive mice were back-crossed to generate individual founder lines. alpha3 founder line was crossed with beta1 founder line to generate alpha3beta1 line. |
| Additional notes: | Mice present phenotype very similar to human psoriasis disease. |
| Cat. #: | 151549 |
|---|---|
| Research Fields: | Cell biology;Genetics |
| Target: | Alpha3 intergrin, beta1 integrin |
| Disease: | Psoriasis |
| Zygosity: | Heterozygous |
| Phenotype: | Mice present phenotype very similar to human psoriasis disease. |
| Shipping conditions: | Embryo/Spermatoza- Dry Ice |
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| References: |
Carroll et al. 1995. Cell. 83(6):957-68. PMID: 8521519. Suprabasal integrin expression in the epidermis of transgenic mice results in developmental defects and a phenotype resembling psoriasis. |
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