TOV3133D

Patient-matched HGSOC cell line derived from solid tumour at diagnosis for longitudinal studies of treatment-associated disease evolution

Contributors

Inventor Institute
Anne-Marie Mes-Masson and Diane Provencher Centre Hospitalier de L’université de Montréal
SKU: 161899
Product description: TOV3133D was derived from solid tumour from patient 3133 at initial diagnosis, before ovarian cancer chemotherapy. Together with TOV-3133G, OV-3133(R) and OV-3133(R2), it forms a matched HGSOC series sampled from the same patient at diagnosis and subsequent relapse after treatment. The 3133 patient received paclitaxel/carboplatin as primary therapy, followed by additional treatments including doxorubicin, carboplatin, gemcitabine and etoposide. This matched series enables comparison of disease states across a single patient’s treatment trajectory while reducing inter-patient variability.
CRISPR: No
Production details: Solid ovarian tumor derived cell line was established using the scrape method where tumor tissue was scraped into a 100mm plate with complete OSE medium and maintained for 40 days. Medium was replaced weekly.
Cellosaurus ID: CVCL_9T19
Disease: Cancer
Related tools: 161781 ; 161782 ; 161783
Cat. #: 161899
Cancer types: Ovarian cancer
Research Fields: Cancer
Organism: Human
Tissue: Ovary
Morphology: Was able to form semi-compact spheroids
Growth properties: Mixed
Primary citation: Létourneau, et al. 2012. BMC Cancer. 29,12:379. PMID: 22931248
Format: Frozen
Storage conditions: Liquid Nitrogen
Shipping conditions: Dry Ice
Growth medium: OSE medium, 10% FBS, 0.5ug/ml apmphotericin B and 50ug/ml gentamycin sulfate
Temperature: 37° C
Atmosphere: 5% O2 and 5% CO2
Biosafety level: 1
References:

Asare-Werehene, et al. 2023. Cancers (Basel). 30,15(9):2566. PMID: 37174032

Vias, et al. 2023. Elife. 11,12:e83867. PMID: 37166279

Tomas, et al. 2023. J Ovarian Res. 11, 16(1):70. PMID: 37038202

Létourneau, et al. 2012. BMC Cancer. 29,12:379. PMID: 22931248

Related Tools for Cell lines

Cat. # Tool Name
161781 TOV-3133G cell line Key Info View Tool
161782 OV-3133(R) cell line Key Info View Tool
161783 OV-3133(R2) cell line Key Info View Tool

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