Epithelial ovarian cancer cell lines spontaneously derived from ascites of patient diagnosed with high-grade serous ovarian cancer
| Inventor | Institute |
|---|---|
| Anne-Marie Mes-Masson and Diane Provencher | Centre Hospitalier de Luniversité de Montréal |
| SKU: | 161783 |
|---|---|
| Product description: | Epithelial ovarian cancer cell lines spontaneously derived from ascites of patient diagnosed with high-grade serous ovarian cancer at specific time points at diagnosis and relapse (R). Primary treatment included paclitaxel and carboplatin and later treatment included doxorubicin, carboplatin, gemcitabine, and etoposide. |
| Alternate name: | OV-3133(R2) |
| Gender: | Female |
| CRISPR: | No |
| Production details: | Established from the cellular fraction of ascites collected by centrifugation. The cell lines were then maintained for 40 days in OSE with medium replaced weekly. |
| Additional notes: | Patient 3133 received treatment of paclitaxel and carboplatin 1-3 months after sugery and confirmation of ovarian cancer diagnosis. A second sugery 6 months after the first detectede infiltration of the tumor in part of the abdomen. Patient was treated with dxorubicin and later carboplatin and gemcitabine after no significant changes of CA-125 levels were seen. Later imaging presented an increase in tumor mass whereby she was given etoposide orally for eight days. |
| Cellosaurus ID: | CVCL_9T16 |
| Receptors of note: | No |
| Cat. #: | 161783 |
|---|---|
| Cancer types: | Ovarian cancer |
| Research Fields: | Cancer |
| Organism: | Human |
| Tissue: | Derived from ascites of patient diagnosed with high-grade serous ovarian cancer at specific time points at diagnosis and relapse |
| Gender: | Female |
| Morphology: | No expression of the tumor suppressor p53 detected. Strong HER2 expression detected in protein extracts and observed in solid tissues by IHC. Spheroid formation: aggregate |
| Growth properties: | Adherent |
| Primary citation: | Létourneau et al. 2012. BMC Cancer. (12): 379. PMID: 22931248 |
| Shipping conditions: | Dry Ice |
|---|---|
| Growth medium: | OSE medium contains 10% FBS, 0.5ug/mL amphotericin B and 50 ug/mL gentamicin |
| Atmosphere: | Hypoxic condition of 5%O2 and 5%CO2 |
| References: |
Tomas et al. 2023. J Ovarian Res. 11 16(1):70. PMID: 37038202 Vias et al. 2023. Elife. 11 12:e83867. PMID: 37166279 Jubelin et al. 2022. Cell Biosci. 11 12(1):155. PMID: 36089610 Canals et al. 2022. Front Oncol. 4 12:856424. PMID: 35600398 |
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