FLYRD18 Cell Line

A human retroviral packaging cell line used to produce high-titre, human serum-resistant recombinant retroviral vectors for gene transfer and gene therapy research. Save 30% on this cell line this summer. Use code SUM26CELL at checkout.

Contributors

Inventor Institute
Mary Collins The Institute of Cancer Research
SKU: 151446
Product description: The FLYRD18 Packaging cell line enables production of high-titer, human complement-resistant recombinant retroviruses, with significantly reduced probability of replication-competent retrovirus generation.
Conditional: Yes
Production details: Human; for details of production of FLYRD18 cell line see Cosset et al. 1995. Journal of Virology. 69:7430-36. PMID: 7494248
Cellosaurus ID: CVCL_8871
Parental cell line: HT 1080
Disease: Cancer
Cat. #: 151446
Provenance and Ownership: The FLYRD18 Cell Line is owned by Cancer Research UK. CancerTools supplies the FLYRD18 Cell Line under licence from Cancer Research UK and is the authorised source for its distribution. Sourcing FLYRD18 Cell Line directly from the IP owner ensures authenticity, provenance and compliance with all applicable licensing and research use requirements.
Tool sub type: Continuous
Unit size: 1×10^6 cells / vial
Cancer types: Blood cancer
Research Fields: Genetics
Organism: Human
Model: Packaging
Growth properties: Recombinant retroviral production
Cancer Types In Detail: Fibrosarcoma
Format: Frozen
Shipping conditions: Dry ice
Growth medium: For recommended growth and recombinant retrovirus production conditions see Cosset F et al, Journal of Virology, 1995, v69 pp7430-7436 & Takeuchi Y et al, Journal of Virology, 1994, v68 pp8001-8007
References:

Production of retroviral vectors for gene therapy with the human packaging cell line FLYRD18.

Cosset et al. 1995. J Virol. 69(12):7430-6. PMID: 7494248.

High-titer packaging cells producing recombinant retroviruses resistant to human serum.

Takeuchi et al. 1994. J Virol. 68(12):8001-7. PMID: 7966590.

Type C retrovirus inactivation by human complement is determined by both the viral genome and the producer cell.

Images

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FLYRD18 Cell Line. 24 hours post plating. Image courtesy of the European Collection of Authenticated Cell Cultures (ECACC).

Citations And Reviews

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