1BR PBRM1 KO4 cell line

1BR3-hTERT cell line knockout for PBRM1 (clone 4)

Contributors

Inventor Institute
Jessica Downs, Hugang Feng The Institute of Cancer Research
Cat. #: 161849
Organism: Human
Tissue: skin
Gender: Male
Model: Genetically modified ; immortalised non-cancer cells
Morphology: Fibroblast
Growth properties: Adherent
Product description: 1BR3-hTERT cell line knockout for PBRM1 (clone 4). This cell line has been used for genotypic screening of cancer to predict response to immunotherapies. Specifically to identify functional proteins involved in chromatin re-modelling and how their loss-of-function can regulate DNA damage-induced inflammatory signalling and sensitivity to T-cell-mediated cell killing.
Gender: Male
CRISPR: Yes
Conditional: No
Parental cell line: 1BR3-hTERT
Model description: PBRM1 knockout
Products or characteristics of interest: Gene loss-of-function, chromatin-remodelling, DNA damage, cell cycle response, regulation of t-cell-mediated cell killing.
Format: Frozen
Storage conditions: Liquid Nitrogen
Shipping conditions: Dry ice
Growth medium: DMEM + 10S + 1% Penicillin/Streptomycin
Temperature: 37C
Atmosphere: 5% CO2 in air
Biosafety level: 1

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