TIGAR (TP53 induced glycolysis and apoptosis regulator) is a novel p53-inducible gene, that shows similarity to the bisphosphatase domain of the biFn enzyme 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase, the main regulator of glycolysis.
| Inventor | Institute |
|---|---|
| Karen Vousden | Cancer Research UK, Glasgow: The Beatson Institute |
| Cat. #: | 151312 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Apoptosis and autophagy;Cancer;Genetics |
| Application: | ChIP ; IP ; WB |
| Target: | TIGAR |
| Reactivity: | Human |
| Clone: | 9C10 |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | TIGAR (TP53 induced glycolysis and apoptosis regulator) is a novel p53-inducible gene, that shows similarity to the bisphosphatase domain of the bifunctional enzyme 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase, the main regulator of glycolysis. TIGAR functions to lower fructose-2,6-bisphosphate levels in cells, resulting in an inhibition of glycolysis, and an overall decrease in intracellular reactive oxygen species (ROS) levels, correlating with a decreased sensitivity to apoptosis. |
|---|---|
| Conjugation: | Unconjugated |
| Isotype: | IgG2b |
| Molecular weight: | 30 kDa |
| Immunogen: | A 15-amino acid peptide corresponding to the exon COOH-terminal region of human TIGAR protein (CMNLQDHLNGLTETR). |
| Myeloma used: | Sp2/0-Ag14 |
| Target background: | TIGAR (TP53 induced glycolysis and apoptosis regulator) is a novel p53-inducible gene, that shows similarity to the bisphosphatase domain of the biFn enzyme 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase, the main regulator of glycolysis. TIGAR functions to lower fructose-2,6-bisphosphate levels in cells, resulting in an inhibition of glycolysis, and an overall decrease in intracellular reactive oxygen species (ROS) levels, correlating with a decreased sensitivity to apoptosis. |
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| Format: | Liquid |
|---|---|
| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Bensaad et al. 2006. Cell. 126(1):107-20. PMID: 16839880. TIGAR, a p53-inducible regulator of glycolysis and apoptosis. |
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