Anti-CD8 [14] mAb

Clone 14 is recommended for: the detection of immunoregulatory T cell subset imbalances in autoimmune disorders and immunodeficiency states, categorisation of T cell acute lymphoblastic leukaemia and lymphoblastic lymphoma in conjunction with other antigens and determination of CD4/CD8 ratios in immune deficiencies, rheumatoid arthritis and multiple sclerosis.

Contributors

Inventor Institute
Nancy Hogg Cancer Research UK, London Research Institute: Lincoln's Inn Fields
Cat. #: 151035
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Cancer;Immunology;Stem cell biology
Application: ELISA ; FACS ; IHC ; IP
Target: CD8
Reactivity: Human
Clone: 14
Host: Mouse
Class: Monoclonal
Alternate name: Leu2
Product description: Clone 14 is recommended for: the detection of immunoregulatory T cell subset imbalances in autoimmune disorders and immunodeficiency states, categorisation of T cell acute lymphoblastic leukaemia and lymphoblastic lymphoma in conjunction with other antigens and determination of CD4/CD8 ratios in immune deficiencies, rheumatoid arthritis and multiple sclerosis.
Conjugation: Unconjugated
Isotype: IgG1
Immunogen: Fibronectin-purified human monocytes
Myeloma used: Sp2/0-Ag14
Target background: CD8 is a T cell co-receptor that recognises, together with the T cell receptor, MHC class I molecules. CD8 is present on human suppressor / cytotoxic T cells, 30% of circulating T cells. Clone 14 is recommended for: the detection of immunoregulatory T cell subset imbalances in autoimmune disorders and immunodeficiency states, categorisation of T cell acute lymphoblastic leukaemia and lymphoblastic lymphoma in conjunction with other antigens and determination of CD4/CD8 ratios in immune deficiencies, rheumatoid arthritis and multiple sclerosis.
Format: Liquid
Concentration: 1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice
References:

Hogg et al. 1999. J Clin Invest. 103(1):97-106. PMID: 9884339.

Images

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Adapted from Xiao F; Ma L; Zhao M; Huang G; Mirenda V; Dorling A; Lechler R; Lombardi G. Ex vivo expanded human regulatory T cells delay islet allograft rejection via inhibiting islet-derived monocyte chemoattractant protein-1 production in CD34+ stem cells-reconstituted NOD-scid IL2r?null mice. PLoS One. 2014 Mar 3;9(3)

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