Anti-Phospho RacGAP1 (Ser157) [pS157 HsCyk-4]

HsCyk-4 (or MgcRacGAP) is a subunit of the centralspindlin, and contains a GTPase activator protein (GAP) domain and directly interacts with the GTP exchange factor (GEF) Ect2, and both HsCyk-4 and Ect2 are essential for equatorial recruitment of the RhoA GTPase, the master regulator of actomyosin dynamics during cytokinesis. Plk1 binds and directly phosphorylates the HsCyk-4.

Contributors

Inventor Institute
Mark Petronczki Cancer Research UK, London Research Institute: Clare Hall Laboratories
Cat. #: 151587
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Cell biology
Application: IF ; IP ; WB
Target: pS157 HsCyk-4 (MgcRacGAP and RacGAP1)
Reactivity: Human ; Mouse ; Rat
Clone: pS157 HsCyk-4
Host: Rabbit
Class: Polyclonal
Alternate name: Cyk-4
Product description: HsCyk-4 (or MgcRacGAP) is a subunit of the centralspindlin, and contains a GTPase activator protein (GAP) domain and directly interacts with the GTP exchange factor (GEF) Ect2, and both HsCyk-4 and Ect2 are essential for equatorial recruitment of the RhoA GTPase, the master regulator of actomyosin dynamics during cytokinesis. Plk1 binds and directly phosphorylates the HsCyk-4.
Conjugation: Unconjugated
Immunogen: Synthetic phospho-peptide ILSDI-pS-FDKTD corresponding to HsCyk-4 aa 152-162 (human)
Target background: HsCyk-4 (or MgcRacGAP) is a subunit of the centralspindlin, and contains a GTPase activator protein (GAP) domain and directly interacts with the GTP exchange factor (GEF) Ect2, and both HsCyk-4 and Ect2 are essential for equatorial recruitment of the RhoA GTPase, the master regulator of actomyosin dynamics during cytokinesis. Plk1 binds and directly phosphorylates the HsCyk-4.
Format: Liquid
Concentration: 0.9-1.1 mg/ml
Storage conditions: -80° C
Shipping conditions: Dry ice

Images

View Gallery
Putative molecular mechanism

Related Tools for Antibodies

Cat. # Tool Name
151031 Anti-RuvA [RuvA 12C6] Key Info View Tool
151017 Anti-MBP [R29.6] Key Info View Tool
151026 Anti-FCGR1 [10.1] mAb Key Info View Tool
151028 Anti-Cytochrome P450 2C2, 2B1/2 [h7] Key Info View Tool
151035 Anti-CD8 [14] mAb Key Info View Tool

Tool enquiry

Please ensure you use your organisation email address rather than personal where possible, as this helps us locate your organisation in our system faster.

Please note we may take up to three days to respond to your enquiry.

CancerTools.org uses the contact information provided to respond to you about our research tools and service. For more information please review our privacy policy.