Anti-Phospho RacGAP1 (Ser157) [pS157 HsCyk-4]

HsCyk-4 (or MgcRacGAP) is a subunit of the centralspindlin, and contains a GTPase activator protein (GAP) domain and directly interacts with the GTP exchange factor (GEF) Ect2, and both HsCyk-4 and Ect2 are essential for equatorial recruitment of the RhoA GTPase, the master regulator of actomyosin dynamics during cytokinesis. Plk1 binds and directly phosphorylates the HsCyk-4.

Contributors

Inventor Institute
Mark Petronczki Cancer Research UK, London Research Institute: Clare Hall Laboratories
Cat. #: 151587
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Cell biology
Application: IF ; IP ; WB
Target: pS157 HsCyk-4 (MgcRacGAP and RacGAP1)
Reactivity: Human ; Mouse ; Rat
Clone: pS157 HsCyk-4
Host: Rabbit
Class: Polyclonal
Alternate name: Cyk-4
Product description: HsCyk-4 (or MgcRacGAP) is a subunit of the centralspindlin, and contains a GTPase activator protein (GAP) domain and directly interacts with the GTP exchange factor (GEF) Ect2, and both HsCyk-4 and Ect2 are essential for equatorial recruitment of the RhoA GTPase, the master regulator of actomyosin dynamics during cytokinesis. Plk1 binds and directly phosphorylates the HsCyk-4.
Conjugation: Unconjugated
Immunogen: Synthetic phospho-peptide ILSDI-pS-FDKTD corresponding to HsCyk-4 aa 152-162 (human)
Target background: HsCyk-4 (or MgcRacGAP) is a subunit of the centralspindlin, and contains a GTPase activator protein (GAP) domain and directly interacts with the GTP exchange factor (GEF) Ect2, and both HsCyk-4 and Ect2 are essential for equatorial recruitment of the RhoA GTPase, the master regulator of actomyosin dynamics during cytokinesis. Plk1 binds and directly phosphorylates the HsCyk-4.
Format: Liquid
Concentration: 0.9-1.1 mg/ml
Storage conditions: -80° C
Shipping conditions: Dry ice

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Putative molecular mechanism

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