Muscleblind-like protein 1 (MBNL1) is well characterized in its role in Myotonic dystrophy, atype of muscular dystrophy and long term genetic disorder that effects muscle function. MBLN1 regulates alternative splicing and acts as both an activator and repressor in terminal muscle differentiation. Defects in its repressor activity have been shown to lead to muscular diseases.
| Institute |
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| University of Florida |
| SKU: | 158409 |
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| Product description: | Muscleblind-like protein 1 (MBNL1) is well characterized in its role in Myotonic dystrophy, atype of muscular dystrophy and long term genetic disorder that effects muscle function. MBLN1 regulates alternative splicing and acts as both an activator and repressor in terminal muscle differentiation. Defects in its repressor activity have been shown to lead to muscular diseases. |
| Alternate name: | Muscleblind Like Splicing Regulator 1; MBNL1 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 kappa |
| Immunogen: | Recombinant MBNL1 fusion protein of human origin |
| Cat. #: | 158409 |
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| Unit size: | 100 ug |
| Research Fields: | Genetics |
| Application: | WB ; IHC ; IF ; IP |
| Target: | Muscleblind-like protein 1 |
| Reactivity: | Human ; Rat ; Mouse |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | Muscleblind-like protein 1 (MBNL1) is well characterized in its role in Myotonic dystrophy, atype of muscular dystrophy and long term genetic disorder that effects muscle function. MBLN1 regulates alternative splicing and acts as both an activator and repressor in terminal muscle differentiation. Defects in its repressor activity have been shown to lead to muscular diseases. |
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| Format: | Liquid |
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| Shipping conditions: | Dry ice |
| References: |
Mankodi et al. 2003. Ann Neurol. 54(6):760-8. PMID: 14681885. |
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