Clone 24 may be used as a reporter of the activation state of the CD11/CD18 integrins and can also be induced following exposure with Mg2+ or Mn2+.
| Inventor | Institute |
|---|---|
| Nancy Hogg | Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| SKU: | 151040 |
|---|---|
| Product description: | Clone 24 may be used as a reporter of the activation state of the CD11/CD18 integrins and can also be induced following exposure with Mg2+ or Mn2+. |
| Alternate name: | Integrin Subunit Alpha L; Leukocyte Function-Associated Molecule 1 Alpha Chain; CD11 Antigen-Like Family Member A; Antigen CD11A (P18); LFA-1A; CD11A; Antigen CD11A (P18); Lymphocyte Function-Associated Antigen 1; Lymphocyte Function-Associated Antigen 1; Alpha Polypeptide; Integrin Gene Promoter; Alpha Polypeptide; Integrin Alpha L; CD11a Antigen; LFA-1; LFA1A |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Molecular weight: | 95 kDa and 180 kDa |
| Immunogen: | Fibronectin-purified human monocytes . |
| Myeloma used: | Sp2/0-Ag14 |
| Cat. #: | 151040 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cell biology |
| Application: | FACS ; IHC ; IF ; IP ; RIA ; WB |
| Target: | Activation epitope on integrin beta 2(CD18) subunit |
| Reactivity: | Human |
| Clone: | 24 |
| Host: | Mouse |
| Class: | Monoclonal |
| Primary citation: | Horton et al. 1985. Cancer Res. 45(11 Pt 2):5663-9. PMID: 4053038. |
| Target background: | Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Integrin beta2 (CD18) associates with integrin alpha L (CD11a) to form the leukocyte function-associated antigen-1 (LFA-1), integrin alpha M (CD11b) to form Complement Receptor 3 (CR3), integrin alpha X (CD11c) to form Complement Receptor 4 (CR4) and with CD11d to form p150,95. Each integrin receptor can bind various Intercellular adhesion molecules (ICAMs) and matrix molecules. |
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| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Drewry et al. 2019. Nat Microbiol. 4(11):1951-1963. PMID: 31332383. Chen et al. 2019. Nanoscale. 11(12):5377-5394. PMID: 30849160. Yuan et al. 2018. Eur J Cardiothorac Surg. 53(2):400-408. PMID: 28950359. Laufer et al. 2018. Front Immunol. 9:3115. PMID: 30692994. Manwani et al. 2015. Am J Hematol. 90(5):381-5. PMID: 25616042. Chen et al. 2010. Proc Natl Acad Sci U S A. 107(33):14727-32. PMID: 20679211. Requirement of open headpiece conformation for activation of leukocyte integrin alphaXbeta2. Stanley et al. 2008. EMBO J. 27(1):62-75. PMID: 18079697. Intermediate-affinity LFA-1 binds alpha-actinin-1 to control migration at the leading edge of the T cell. Smith et al. 2005. J Cell Biol. 170(1):141-51. PMID: 15983060. A talin-dependent LFA-1 focal zone is formed by rapidly migrating T lymphocytes. McDowall et al. 2003. J Clin Invest. 111(1):51-60. PMID: 12511588. A novel form of integrin dysfunction involving beta1, beta2, and beta3 integrins. Hogg et al. 1985. Cell Immunol. 92(2):247-53. PMID: 2581704. An anti-human monocyte/macrophage monoclonal antibody, reacting most strongly with macrophages in lymphoid tissue. |
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