ICAMs are members of the immunoglobulin superfamily that is characterised by the presence of immunoglobulin-like domains. ICAM-1 is expressed in haemopoietic cells and vascular endothelium.
| Inventor | Institute |
|---|---|
| Nancy Hogg | Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| SKU: | 151036 |
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| Product description: | ICAMs are members of the immunoglobulin superfamily that is characterised by the presence of immunoglobulin-like domains. ICAM-1 is expressed in haemopoietic cells and vascular endothelium. Cytokine activation causes ICAM-1 expression in other cell types such as fibroblasts and keratinocytes. ICAM-1 is involved in leukocyte recruitment and inflammation. ICAM-1 binds LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). |
| Alternate name: | Intercellular Adhesion Molecule 1; Major Group Rhinovirus Receptor; ICAM-1; Cell Surface Glycoprotein P3.58; Human Rhinovirus Receptor; P3.58; CD54; BB2 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Molecular weight: | 85-115 kDa |
| Immunogen: | Rheumatoid synovial cells and human monocytes. |
| Myeloma used: | Sp2/0-Ag14 |
| Cat. #: | 151036 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cell biology; Immunology; Stem cell biology; Tissue-specific biology |
| Application: | FACS ; IHC ; IP ; Fn |
| Target: | ICAM1 (CD54) |
| Reactivity: | Human |
| Clone: | 15.2 |
| Host: | Mouse |
| Class: | Monoclonal |
| Primary citation: | Dransfield et al. 1992. J Cell Biol. 116(6):1527-35. PMID: 1541641 |
| Target background: | ICAMs are members of the immunoglobulin superfamily that is characterised by the presence of immunoglobulin-like domains. ICAM-1 is expressed in haemopoietic cells and vascular endothelium. Cytokine activation causes ICAM-1 expression in other cell types such as fibroblasts and keratinocytes. ICAM-1 is involved in leukocyte recruitment and inflammation. ICAM-1 binds LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). |
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| Format: | Liquid |
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| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -20° C |
| Shipping conditions: | Dry ice |
| References: |
Vsquez et al. 2016. Microbes Infect. :. PMID: 27717894. Plasmodium falciparum isolates from patients with uncomplicated malaria promote endothelial inflammation. Intercellular adhesion molecule 1 serves as a primary cognate receptor for the Type IV pilus of nontypeable Haemophilus influenzae. Novotny et al. 2016. Cell Microbiol. :. PMID: 26857242. Perturbation of adhesion molecule-mediated chondrocyte-matrix interactions by 4-hydroxynonenal binding: implication in osteoarthritis pathogenesis. El-Bikai et al. 2010. Arthritis Res Ther. 12(5):R201. PMID: 20977750. Conway et al. 2010. Am J Physiol Heart Circ Physiol. 298(2):H367-74. PMID: 19915176. Endothelial cell responses to atheroprone flow are driven by two separate flow components: low time-average shear stress and fluid flow reversal. Lauriello et al. 2005. Acta Otorhinolaryngol Ital. 25(5):284-91. PMID: 16602327. A two-year course of specific immunotherapy or of continuous antihistamine treatment reverse eosinophilic inflammation in severe persistent allergic rhinitis. Stanley et al. 2000. Biochem J. 351(Pt 1):79-86. PMID: 10998349. The second domain of intercellular adhesion molecule-1 (ICAM-1) maintains the structural integrity of the leucocyte function-associated antigen-1 (LFA-1) ligand-binding site in the first domain. Dransfield et al. 1992. J Cell Biol. 116(6):1527-35. PMID: 1541641. Interaction of leukocyte integrins with ligand is necessary but not sufficient for function. |
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