Anti-CAR Whitlow Linker [1C3C3]

The anti-CAR Whitlow linker peptide 1C3C3 clone has been developed to detect cells expressing Whitlow linker-containing CARs with different antigen specificities, including those harbouring the widely employed anti-CD19 FMC63-derived scFv as well as other scFvs, such as those targeting B-cell maturation antigen (BCMA) or CD33. It has been demonstrated to have a mean KD of 1 to 2.6 µM when tested for binding kinetics against FMC63-Whitlow scFv protein and the Whitlow peptide. No binding to G4S4 peptide was found. In addition, the 1C3C3 antibody has been demonstrated to stain engineered T cells expressing 1H7- or FMC63-Whiltow, but not 1H7- or…