Cat. #156467
Selective CB2R photoaffinity probe (LEI-121) small molecule (tool compound)
Cat. #: 156467
Sub-type: Fluorescent Probe
Availability: Please enquire for quantities and pricing
Application: Enables target engagement studies and visualisation of endogenously expressed CB2R.
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Institute: Leiden University and Leiden University Medical Center
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Tool name: Selective CB2R photoaffinity probe (LEI-121) small molecule (tool compound)
- Research fields: Drug development;Cell biology
- Molecular formula: C31H29F4N6O4S [M+H]+
- Tool sub type: Fluorescent Probe
- Description: Photoreactive probe to study the type 2 cannabinoid receptor (CB2R). LEI121 is the first CB2R-selective bifunctional probe that covalently captures CB2R upon photoactivation. An incorproated alkyne serves as ligation handle for the introduction of reporter groups.
- Application: Enables target engagement studies and visualisation of endogenously expressed CB2R.
- Molecular weight: 657
- Additional notes: Using proteomics, LEI-121 has shown to identify multidrug resistance protein 1, protein disulfide-isomerase, glutathione S-transferase Mu 6, 26S proteasome non-ATPase regulatory subunit 3 O and mitochondrial carnitine.acylcarnitine carrier protein.
Application Details
- Application: Enables target engagement studies and visualisation of endogenously expressed CB2R.
References
- Soethoudt et al. 2018. Cannabis Cannabinoid Res. 3(1):136-151. PMID: 29992186.
- Soethoudt et al. 2018. J Am Chem Soc. 140(19):6067-6075. PMID: 29420021.
