Cat. #161586
Photo-activated Histone Deacetylase Inhibitor
Cat. #: 161586
Sub-type: Inhibitor
Availability: 3-4 weeks
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Anthony Dear
Institute: Monash University
Primary Citation: Sama GR et al. Bioorg Med Chem Lett. 2020. 30(16):127291. PMID: 32631513
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Tool name: Photo-activated Histone Deacetylase Inhibitor
- Alternate name: Photo-MCT-3, Caged MCT-3. Photo-metacept-3, Caged metacept-3
- Cancer: Other
- Cancers detailed: Other
- Molecular formula: C27H29N3O10S
- Chemical name: 4-(2-methoxy-4-(1-((3'-(methylsulfonamido)-[1,1'-biphenyl]-4-carboxamido)oxy)ethyl)-5-nitrophenoxy)butanoic acid
- Tool sub type: Inhibitor
- Primary target: Histone Deacetylase (HDAC)
- Description: Photo-activatable HDAC inhibitors offer a useful tool for targeted control of antiproliferative activity and other molecular effects in a wide range of biological systems
- Is the structure published: Yes
- Pubchem id: Sama GR et al. Bioorg Med Chem Lett. 2020. 30(16):127291. PMID: 32631513
- Molecular weight: MW 587.3 Da
- Solubility: DMSO
- Additional notes: Ultraviolet (UV) 365nm light source required for cleavage to active compound MCT-3. Parent compound MCT-3 has been used extensively as a HDACi by the originating group. Please search Pubmed for relevant publications.
Handling
- Format: Dry
- Purity: >95% HPLC
- Storage conditions: Store powder@RT, Dissolved -20oC
- Shipping conditions: RT
Target Details
- Primary target: Histone Deacetylase (HDAC)
Related Tools
- Related tools: Liu H et al. Cardiovasc Eng Technol. 2021. 12(4):466-473. PMID: 33709249
References
- Liu H et al. Cardiovasc Eng Technol. 2021. 12(4):466-473. PMID: 33709249
