Cat. #151880
AKR1C3 inhibitor CRT0093964 Small Molecule (Tool Compound)
Cat. #: 151880
Sub-type: Inhibitor
Availability: Please enquire for quantities and pricing
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Laurent Rigoreau
Institute: Cancer Research Technology
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Tool name: AKR1C3 inhibitor CRT0093964 Small Molecule (Tool Compound)
- Research fields: Cell signaling and signal transduction;Metabolism;Neurobiology
- Molecular formula: C15H20CIN3O2
- Tool sub type: Inhibitor
- Primary target: Type 5 17-?-Hydroxysteroid Dehydrogenase (AKR1C3)
- Description: CRT0093964 is a highly potent and selective inhibitor of the Type 5 17-?-Hydroxysteroid Dehydrogenase (AKR1C3).
- Purpose: Inhibitor
- Selectivity: Displays >100-fold selectivity against AKR1C1, AKR1C2 and AKR1C4. Does not display any COX (cyclooxygenase) inhibition at 10 ÂľM in whole blood assay.
- Iupac: 4-(4-Chloro-phenyl)-piperazin-1-yl]-morpholin-4-yl-methanone
- Molecular weight: 309.79
- Additional notes: Referred to as A9 in Khanim et al., 2014.
Handling
- Purity: 309.79 g/mol
- Shipping conditions: Dry Ice
Target Details
- Primary target: Type 5 17-?-Hydroxysteroid Dehydrogenase (AKR1C3)
- Ic50: IC50 = 88 nM
Related Tools
- Related tools: AKR1C3 inhibitor CRT0083914 Small Molecule (Tool Compound) ; AKR1C3 inhibitor CRT0036521 Small Molecule (Tool Compound)
References
- Khanim et al. 2014. Br J Cancer. 110(6):1506-16. PMID: 24569460.
