#158322

NBQ-48 small molecule

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Cat. #158322

NBQ-48 small molecule

Cat. #: 158322

Sub-type: Inhibitor

Availability: Please enquire for quantities and pricing

Application: cell hypoxia marker; fluorescence-based multiplex ELISA

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: Osvaldo Cox (Retired), Beatriz Zayas

Institute: Universidad Ana G. Mendez

Tool Details
Handling
Target Details
Application Details
References

Tool Details

*FOR RESEARCH USE ONLY

  • Tool name: NBQ-48 small molecule
  • Research fields: Cancer;Cell biology
  • Molecular formula: C22H26CIN3O2
  • Tool sub type: Inhibitor
  • Description: Inhibitor of growth in several cancer cell line models. This small molecule can also be used as a cell hypoxia marker in 2D and 3D colon cancer cell models.
  • Application: cell hypoxia marker; fluorescence-based multiplex ELISA
  • Iupac: 7-benzyl-3- nitrobenzimidazo[3,2-a]quinolinium chloride
  • Molecular weight: 389.8348
  • Solubility: 3 mM in water, 10ľM DMSO; 100 ľg/mL in DMSO

Handling

  • Purity: 389.8348 g/mol
  • Storage conditions: 2-5° C in solution
  • Shipping conditions: Dry Ice

Target Details

  • Ic50: 100 uM (COLO205 cells under hypoxic conditions); 128 uM +/- 3 uM (U937 cells)

Application Details

  • Application: cell hypoxia marker; fluorescence-based multiplex ELISA

References

  • VĂŠlez et al. 2017. Open Med Chem J. 11:54-65. PMID: 28761559.
  • Otero et al. 2015. J Cancer Res Ther Oncol. 1:. PMID: 26086027.
  • Vivas-MejĂ­a et al. 1998. Mol Cell Biochem. 178(1-2):203-12. PMID: 9546601.