#151889

DNA-PK inhibitor NU7441 Small Molecule (Tool Compound)

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Cat. #151889

DNA-PK inhibitor NU7441 Small Molecule (Tool Compound)

Cat. #: 151889

Sub-type: Inhibitor

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Application: NU7441 intraperitoneally administrated at dose of 10 mg/kg maintains for at least 4 hours shows nontoxic and increases etoposide-induced tumor growth delay 2-fold in mice bearing SW620 xenografts. NU7441 increases the persistence of γH2AX foci after ionizing radiation–induced or etoposide-induced DNA damage. NU7441 (0.5 μM or 1 μM) appreciably increases G2-M accumulation induced by ionizing radiation, etoposide, and doxorubicin in both SW620 and LoVo cells. NU7441 causes persistence of d...

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Contributor

Inventor: Bernard Golding ; Laurent Rigoreau

Institute: Newcastle University

Tool Details
Handling
Target Details
Application Details
References

Tool Details

*FOR RESEARCH USE ONLY

  • Tool name: DNA-PK inhibitor NU7441 Small Molecule (Tool Compound)
  • Alternate name: DNA-dependent protein kinase (DNA-PK) inhibitor NU7441
  • Research fields: Cell signaling and signal transduction;Genetics
  • Molecular formula: C25H19NO3S
  • Tool sub type: Inhibitor
  • Primary target: DNA-dependent protein kinase (DNA-PK)
  • Description: NU7441 is a highly potent and selective DNA-PK inhibitor.
  • Application: NU7441 intraperitoneally administrated at dose of 10 mg/kg maintains for at least 4 hours shows nontoxic and increases etoposide-induced tumor growth delay 2-fold in mice bearing SW620 xenografts. NU7441 increases the persistence of ÎłH2AX foci after ionizing radiation–induced or etoposide-induced DNA damage. NU7441 (0.5 ÎźM or 1 ÎźM) appreciably increases G2-M accumulation induced by ionizing radiation, etoposide, and doxorubicin in both SW620 and LoVo cells. NU7441 causes persistence of d...
  • Purpose: Inhibitor
  • Selectivity: Also inhibits PI3K with IC50 of 5 ÎźM in cell-free assays.
  • Molecular weight: 413.49 g/mol

Handling

  • Purity: 413.49 g/mol
  • Shipping conditions: Dry Ice

Target Details

  • Primary target: DNA-dependent protein kinase (DNA-PK)
  • Ic50: 14 nM

Application Details

  • Application: NU7441 intraperitoneally administrated at dose of 10 mg/kg maintains for at least 4 hours shows nontoxic and increases etoposide-induced tumor growth delay 2-fold in mice bearing SW620 xenografts. NU7441 increases the persistence of ÎłH2AX foci after ionizing radiation–induced or etoposide-induced DNA damage. NU7441 (0.5 ÎźM or 1 ÎźM) appreciably increases G2-M accumulation induced by ionizing radiation, etoposide, and doxorubicin in both SW620 and LoVo cells. NU7441 causes persistence of d...

References

  • Zhao et al. 2006. Cancer Res. 66(10):5354-62. PMID: 16707462.
  • Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441.
  • Leahy et al. 2004. Bioorg Med Chem Lett. 14(24):6083-7. PMID: 15546735.
  • Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries.