Heat shock protein 70 (HSP70) inhibitor JG-345

JG-345 was designed as a small molecule with greater stability and potency to inhibit members of the heat shock protein 70 (Hsp70) family of molecular chaperones.

Contributors

Inventor Institute
Jason Gestwicki University of Michigan
Cat. #: 157978
Tool sub type: Inhibitor
Research Fields: Cancer
Purpose: Inhibitor
Product description: The benzothiazole rhodacyanines, MKT-077 analogue, JG-345 was designed as a small molecule with greater stability and potency to inhibit members of the heat shock protein 70 (Hsp70) family of molecular chaperones. Inhibiting Hsp70 chaperones induce apoptosis in breast cancer cell lines. This inhibitor would be useful in the study of Hsp70 chaperones and oncology research.
Primary target: Heat shock protein 70 (HSP70)
Shipping conditions: Dry Ice
References:

Shao et al. 2020. Bioorg Med Chem Lett. 30(5):126954. PMID: 31952963.

Taguwa et al. 2019. Cell Rep. 26(4):906-920.e3. PMID: 30673613.

Rinaldi et al. 2018. ACS Chem Biol. 13(11):3142-3152. PMID: 30372610.

Shao et al. 2018. J Med Chem. 61(14):6163-6177. PMID: 29953808.

Young et al. 2016. Cell Chem Biol. 23(8):992-1001. PMID: 27499529.

Li et al. 2013. ACS Med Chem Lett. 4(11):. PMID: 24312699.

Rousaki et al. 2011. J Mol Biol. 411(3):614-32. PMID: 21708173.

Related Tools for Small molecules

Cat. # Tool Name
151843 AKR1C3 inhibitor CRT0036521 Small Molecule (Tool Compound) Key Info View Tool
151879 AKR1C3 inhibitor CRT0083914 Small Molecule (Tool Compound) Key Info View Tool
152754 CDK2 inhibitor NU6301 Small Molecule (Tool Compound) Key Info View Tool
152785 Mitochondrial Luminophore Small Molecule (Tool Compound) Key Info View Tool
152786 Nucleolar Luminophore Ag-1 Small Molecule (Tool Compound) Key Info View Tool

Tool enquiry

Please ensure you use your organisation email address rather than personal where possible, as this helps us locate your organisation in our system faster.

Please note we may take up to three days to respond to your enquiry.

CancerTools.org uses the contact information provided to respond to you about our research tools and service. For more information please review our privacy policy.