FragLites Screen (DMSO)

A set of 31 compounds designed to express a <U+0093>pharmacophore doublet<U+0094> of two hydrogen bond acceptors or a donor and an acceptor displayed on an aromatic scaffold and incorporating a heavy halogen atom.

Contributors

Inventor Institute
Michael J Waring ; Martin E M Noble ; Daniel Wood ; Mathew Martin ; Duncan C Miller Northern Institute For Cancer Research, Newcastle University
Additional notes: The compound set is available dispensed in an assay ready ECHO plate. Format: 10uL per compound @ 500mM in DMSO Library Plate Source Well Library Name SMILES FragLite Set 1 A1 FL1 BrC1=CNN=C1 FragLite Set 1 A2 FL2 IC1=CNN=C1 FragLite Set 1 A3 FL3 BrC1=CON=C1 FragLite Set 1 A4 FL4 NC1=NC=CC(Br)=C1 FragLite Set 1 A5 FL5 NC1=NC=CC(I)=C1 FragLite Set 1 A6 FL6 O=C1C=C(Br)C=CN1 FragLite Set 1 A7 FL7 O=C1C=C(I)C=CN1 FragLite …
Storage conditions: Keep frozen ~-10°C
Shipping conditions: Dry Ice
Solubility: DMSO
References:

Wood et al. 2019. J Med Chem. 62(7):3741-3752. PMID: 30860382.

Davison et al. 2022. Journal of Medicinal Chemistry. 65(22): 15416–15432 PMID: 36367089

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