Cat. #152788
Phosphatidylinositol-4-phosphate 5-kinase inhibitor PIP5K Small Molecule (Collaborative Toolkit)
Cat. #: 152788
Sub-type: Inhibitor
Availability: Please enquire for quantities and pricing
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Institute: Cancer Research Technology â AstraZeneca Metabolism Alliance Team
Tool Details
*FOR RESEARCH USE ONLY
- Tool name: Phosphatidylinositol-4-phosphate 5-kinase inhibitor PIP5K Small Molecule (Collaborative Toolkit)
- Tool sub type: Inhibitor
- Primary target: Phosphatidylinositol-4-phosphate 5-kinase (PIP5K)
- Purpose: Inhibitor
- Selectivity: PI4KCA IC50: 20.9 ÂľM PI4KCB IC50: 5.99 ÂľM PI3KÎą IC50: 34.6 ÂľM
- Molecular weight: PIP5Kι IC50: 0.011 ¾MPIP5Kβ IC50: 0.004 ¾MPIP5Kγ IC50: 0.001 ¾M
- Solubility: 15 ÂľM (Aqueous)
Handling
- Purity: 430.5 kDa
Target Details
- Primary target: Phosphatidylinositol-4-phosphate 5-kinase (PIP5K)
- Ic50: PIP5Kι IC50: 0.011 ¾MPIP5Kβ IC50: 0.004 ¾MPIP5Kγ IC50: 0.001 ¾M
Application Details
- Application notes: Cell Permeability: Caco2 permeability: 4.49 x 10-6 cm/s (efflux ratio 3.3)
References
- Andrews et al. 2014. Eur. J. Cancer. 50(6):91
