Phosphatidylinositol-4-phosphate 5-kinase inhibitor PIP5K Small Molecule (Collaborative Toolkit)

A selective inhibitor of phosphatidylinositol-4-phosphate 5-kinase (PIP5K) which demonstrates anti-cancer activity

Contributors

Institute
Cancer Research Technology – AstraZeneca Metabolism Alliance Team
Cat. #: 152788
Tool sub type: Inhibitor
Purpose: Inhibitor
Molecular weight: PIP5Kι IC50: 0.011 ¾MPIP5Kβ IC50: 0.004 ¾MPIP5Kγ IC50: 0.001 ¾M
Selectivity: PI4KCA IC50: 20.9 ÂľM PI4KCB IC50: 5.99 ÂľM PI3KÎą IC50: 34.6 ÂľM
Primary target: Phosphatidylinositol-4-phosphate 5-kinase (PIP5K)
Solubility: 15 ÂľM (Aqueous)
References:

Andrews et al. 2014. Eur. J. Cancer. 50(6):91

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