#152788

Phosphatidylinositol-4-phosphate 5-kinase inhibitor PIP5K Small Molecule (Collaborative Toolkit)

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Cat. #152788

Phosphatidylinositol-4-phosphate 5-kinase inhibitor PIP5K Small Molecule (Collaborative Toolkit)

Cat. #: 152788

Sub-type: Inhibitor

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Contributor

Institute: Cancer Research Technology – AstraZeneca Metabolism Alliance Team

Tool Details
Handling
Target Details
Application Details
References

Tool Details

*FOR RESEARCH USE ONLY

  • Tool name: Phosphatidylinositol-4-phosphate 5-kinase inhibitor PIP5K Small Molecule (Collaborative Toolkit)
  • Tool sub type: Inhibitor
  • Primary target: Phosphatidylinositol-4-phosphate 5-kinase (PIP5K)
  • Purpose: Inhibitor
  • Selectivity: PI4KCA IC50: 20.9 ÂľM PI4KCB IC50: 5.99 ÂľM PI3KÎą IC50: 34.6 ÂľM
  • Molecular weight: PIP5KÎą IC50: 0.011 ÂľMPIP5Kβ IC50: 0.004 ÂľMPIP5KÎł IC50: 0.001 ÂľM
  • Solubility: 15 ÂľM (Aqueous)

Handling

  • Purity: 430.5 kDa

Target Details

  • Primary target: Phosphatidylinositol-4-phosphate 5-kinase (PIP5K)
  • Ic50: PIP5KÎą IC50: 0.011 ÂľMPIP5Kβ IC50: 0.004 ÂľMPIP5KÎł IC50: 0.001 ÂľM

Application Details

  • Application notes: Cell Permeability: Caco2 permeability: 4.49 x 10-6 cm/s (efflux ratio 3.3)

References

  • Andrews et al. 2014. Eur. J. Cancer. 50(6):91