Trex1 -/- Mouse

Model for the human recessive autoimmune disease Aicardi-Goutieres syndrome; potential use for testing of therapeutic agents; identifies a novel immune pathway. Trex1 KO mouse

Contributors

Inventor Institute
Tomas Lindahl Cancer Research UK, London Research Institute: Clare Hall Laboratories
Cat. #: 151578
Research Fields: Drug development;Genetics;Immunology
Target: TREX1
disease: Antiviral-like autoimmunity
Model: Knock-Out
Zygosity: Homozygous
Phenotype: Autoimmunity manifested as inflammatory myocarditis / reduced lifespan
Product description: Model for the human recessive autoimmune disease Aicardi-Goutieres syndrome; potential use for testing of therapeutic agents; identifies a novel immune pathway. Trex1 KO mouse
Conditional: No
Production details: Standard gene-targeting in ES cells using a genomic DNA construct flanking the Trex1 locus in which amino acids 103 to 207 of the Trex1 ORF were replaced by a neomycin resistance gene/polyA signal.
Shipping conditions: Embryo/Spermatoza- Dry Ice
References:

Yang et al. 2007. Cell. 131(5):873-86. PMID: 18045533.

Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease.

Morita et al. 2004. Mol Cell Biol. 24(15):6719-27. PMID: 15254239.

Gene-targeted mice lacking the Trex1 (DNase III) 3'–>5' DNA exonuclease develop inflammatory myocarditis.

Related Tools for Mouse models

Cat. # Tool Name
151556 UNG Mouse Key Info View Tool
151443 GSTP1GSTP2 KO Mouse Key Info View Tool
151444 InvEE Mouse Key Info View Tool
151476 Raf-/- KO Mouse Key Info View Tool
151550 Integrin a6b4 Mouse Key Info View Tool

Tool enquiry

Please ensure you use your organisation email address rather than personal where possible, as this helps us locate your organisation in our system faster.

Please note we may take up to three days to respond to your enquiry.

CancerTools.org uses the contact information provided to respond to you about our research tools and service. For more information please review our privacy policy.