Mouse line with cysteine 75 of AEG-1 mutated to serine. AEG-1/MTDH; palmitoylation; NASH; HCC; mouse model
| Inventor | Institute |
|---|---|
| Devanand Sarkar | Virginia Commonwealth University |
| SKU: | 161681 |
|---|---|
| Product description: | Mouse line with cysteine 75 of AEG-1 mutated to serine. AEG-1-C75S mice might be more prone to developing NASH and HCC which could help design new therapeutic strategies. Findings identify a novel role of AEG-1 palmitoylation regulating NASH and HCC thereby establishing the rationale for using inhibitors of AEG-1 depalmitoylating enzymes for the treatment of NASH and HCC. |
| Conditional: | No |
| CRISPR: | Yes |
| Genetic background: | AEG-1-C75S mice were created in C57BL/6/J background. ATG-1-C75S heterozygotexheterozygote mating was performed to generate AEG-1-WT adn AEG-1-C75S littermates |
| Production details: | Knock-in mice by CRISPR/Cas9 in which Cys75 of AEG-1 was mutated to Ser (AEG-1-C75S). AEG-1-C75S mice were created in C57BL/6/J background. ATG-1-C75S heterozygotexheterozygote mating was performed to generate AEG-1-WT adn AEG-1-C75S littermates |
| Cat. #: | 161681 |
|---|---|
| Cancer types: | Liver cancer |
| Research Fields: | Cancer |
| Disease: | Non-alcoholic fatty liver disease (NAFLD) |
| Model: | Knock-In |
| Strain: | C57BL/6/J |
| Phenotype: | Unaffected litter size of AEG-1-C75S mice compared to WT adn overall showing milder and different phenotype compared to AEG-1-/- mice |
| Primary citation: | Komaniecki et al. Biochemistry 62(2):543-553. PMID: 36548985 |
| References: |
Komaniecki et al. Biochemistry 62(2):543-553. PMID: 36548985 |
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