SAR-22-019F mouse line

Transgenic mouse with hepatocyte-specific overexpression of MDA-9 (Alb/MDA-9)

Contributors

Inventor Institute
Devanand Sarkar Virginia Commonwealth University
Cat. #: 161680
Cancer types: Carcinoma
Research Fields: Cancer
disease: Non-alcoholic fatty liver disease (NAFLD)
Model: Transgenic
Strain: B6CBAF1
Phenotype: Higher tumor burden in livers , increased levels of serum liver enzymes, aspartate aminotransferase (AST), and alanine aminotransferase (ALT) in Alb/MDA-9 mice after 32 weeks
Primary citation: Manna et al. Hepatology doi: 10.1002/hep32797 PMID: 36120720
Product description: Transgenic mouse with hepatocyte-specific overexpression of MDA-9 (Alb/MDA-9). Alb/MDA-9 allows analysis of the role of MDA-9 in HCC development and progression. Alb/MDA-9 allows analysis of the molecular mechanism by which MDA-9 promotes HCC. This mouse line will also be useful in analyzing the role of MDA-9 in other liver diseases such as fibrosis. Findings identify a novel role of MDA-9/SDCBP in hepatocarcinogenesis thereby establishing the rationale for using MDA-9 inhibitors for the…
CRISPR: No
Genetic background: This Alb/MDA-9 transgenic mouse line in B6CBAF1 background was generated by directing the expression of C-terminal HA-tagged human MDA-9/SDCBP under an upstream enhancer region (–10400 to –8500) fused to the 335-bp core region of mouse albumin promoter.
Production details: This Alb/MDA-9 transgenic mouse line in B6CBAF1 background was generated by directing the expression of C-terminal HA-tagged human MDA-9/SDCBP under an upstream enhancer region (–10400 to –8500) fused to the 335-bp core region of mouse albumin promoter.
References:

Manna et al. Hepatology doi: 10.1002/hep32797 PMID: 36120720

Related Tools for Mouse models

Cat. # Tool Name
151478 caMEK1 Mouse Key Info View Tool
151502 CyclinD1-/- KO Mouse Key Info View Tool
151481 DLL1 Floxed Mouse Key Info View Tool
151534 Pdgfrb-Cre Mouse Key Info View Tool
151551 Inva2b1 Mouse Key Info View Tool

Tool enquiry

Please ensure you use your organisation email address rather than personal where possible, as this helps us locate your organisation in our system faster.

Please note we may take up to three days to respond to your enquiry.

CancerTools.org uses the contact information provided to respond to you about our research tools and service. For more information please review our privacy policy.