Pdgfrb-Cre Mouse

Cre expressed under Pdgfrb promoter enabling conditional recombine expression in pericytes and smooth vascular muscle cells (tissue-specific loxP knockout/knockin)

Contributors

Inventor Institute
Ralf H. Adams Cancer Research UK, London Research Institute: Lincoln's Inn Fields
Cat. #: 151534
Research Fields: Cancer;Genetics;Immunology;Tissue-specific biology
Target: Cre recombinase under Pdgfrb promoter
disease: Cancer
Model: Conditional KO
Product description: Cre expressed under Pdgfrb promoter enabling conditional recombine expression in pericytes and smooth vascular muscle cells (tissue-specific loxP knockout/knockin)
Conditional: Yes
Conditional description: Pdgfrb-Cre enables conditional, pericyte and smooth vascular muscle cell knockout/knockin/transgene expression of loxP flanked genes.
Genetic background: A Pdgfrb-Cre transgene vector, containing a genomic Pdgfrb promoter fragment fused to Cre recombinase and a polyA sequence, was injected into fertilised 129/C57BL6 oocytes. Founder lines were backcrossed to establish transgenic lines on a mixed 129/C57BL6 background.
Production details: A Pdgfrb-Cre transgene vector, containing a genomic Pdgfrb promoter fragment fused to Cre recombinase and a polyA sequence, was injected into fertilised 129/C57BL6 oocytes. Founder lines were backcrossed to establish transgenic lines on a mixed 129/C57BL6 background.
Shipping conditions: Embryo/Spermatoza- Dry Ice
References:

Kogata et al. 2009. Genes Dev. 23(19):2278-83. PMID: 19797768.

Integrin-linked kinase controls vascular wall formation by negatively regulating Rho/ROCK-mediated vascular smooth muscle cell contraction.

Foo et al. 2006. Cell. 124(1):161-73. PMID: 16413489.

Ephrin-B2 controls cell motility and adhesion during blood-vessel-wall assembly.

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