p110beta PI3K-D931A (129)

Contributors

Inventor Institute
Bart Vanhaesebroeck Ludwig Institute for Cancer Research
Cat. #: 158388
Research Fields: Cancer
Target: PIK3CB
Model: Knock-In
Phenotype: Mice show prenatal partial lethality at at different embryonic stages (see PMID 26132308 for details). Homozygous male mice that are born are infertile with smaller than normal testicles. They cannot produce offspring.
Genetic background: Knock-in mice in which the endogenous PIK3CB/p110beta PI3K gene is mutated so that it now encodes a p110beta protein with the D931A mutation in the ATP binding site, converting it to a kinase-dead p110beta protein which is expressed at the same level as wild-type p110beta. These mice have been backcrossed onto the sv129 background.
Production details: Knock-in mice in which the endogenous PIK3CB/p110beta PI3K gene is mutated so that it now encodes a p110beta protein with the D931A mutation in the ATP binding site, converting it to a kinase-dead p110beta protein which is expressed at the same level as wild-type p110beta. These mice have been backcrossed onto the sv129 background.
Additional notes: Mice show prenatal partial lethality at at different embryonic stages (see PMID 26132308 for details). Homozygous male mice that are born are infertile with smaller than normal testicles. They cannot produce offspring.
Shipping conditions: Embryo/Spermatoza- Dry Ice
References:

Guillermet-Guibert et al. 2015. PLoS Genet. 11(7):e1005304. PMID: 26132308.

Kulkarni et al. 2011. Sci Signal. 4(168):ra23. PMID: 21487106.

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