K14MycER Mouse

In vivo study of Myc activation in skin; in vivo study of skin cell proliferation & differentiation (sebocytes, epidermis)

Contributors

Inventor Institute
Fiona Watt Cancer Research UK, London Research Institute: Lincoln's Inn Fields
Cat. #: 151563
Research Fields: Cancer;Genetics;Stem cell biology
Target: cMyc protooncogene (Myc) fused with estragen receptor (ER).
disease: Cancer
Phenotype: Skin abnormalities (hyperproliferation; hair follicle; sebaceous gland);
Product description: In vivo study of Myc activation in skin; in vivo study of skin cell proliferation & differentiation (sebocytes, epidermis)
Conditional: Yes
Conditional description: Conditional expression of MycER under Keratin 14 promoter giving tissue-specific epidermal expression
Genetic background: A MycER transgenic vector, containing a c-Myc-2 cDNA fused to the hormone-binding domain of a mutant mouse estragen receptor under the control of the keratin 14 promoter, was injected into fertilised CBA/C57BL6 ooctyes. Founders were backcrossed to establish transgenic lines.
Production details: A MycER transgenic vector, containing a c-Myc-2 cDNA fused to the hormone-binding domain of a mutant mouse estragen receptor under the control of the keratin 14 promoter, was injected into fertilised CBA/C57BL6 ooctyes. Founders were backcrossed to establish transgenic lines.
Shipping conditions: Embryo/Spermatoza- Dry Ice

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