#151563

K14MycER Mouse

Cat. #151563

K14MycER Mouse

Cat. #: 151563

Sub-type: Mouse

Availability: 6-8 weeks

Disease: Cancer

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: Fiona Watt

Institute: Cancer Research UK, London Research Institute: Lincoln's Inn Fields

Tool Details
Handling
Target Details
Related Tools

Tool Details

*FOR RESEARCH USE ONLY

  • Tool name: K14MycER Mouse
  • Research fields: Cancer;Genetics;Stem cell biology
  • Tool sub type: Mouse
  • Disease: Cancer
  • Conditional: Yes
  • Conditional description: Conditional expression of MycER under Keratin 14 promoter giving tissue-specific epidermal expression
  • Description: In vivo study of Myc activation in skin; in vivo study of skin cell proliferation & differentiation (sebocytes, epidermis)
  • Genetic background: A MycER transgenic vector, containing a c-Myc-2 cDNA fused to the hormone-binding domain of a mutant mouse estragen receptor under the control of the keratin 14 promoter, was injected into fertilised CBA/C57BL6 ooctyes. Founders were backcrossed to establish transgenic lines.
  • Phenotype: Skin abnormalities (hyperproliferation; hair follicle; sebaceous gland);
  • Production details: A MycER transgenic vector, containing a c-Myc-2 cDNA fused to the hormone-binding domain of a mutant mouse estragen receptor under the control of the keratin 14 promoter, was injected into fertilised CBA/C57BL6 ooctyes. Founders were backcrossed to establish transgenic lines.

Handling

  • Shipping conditions: Embryo/Spermatoza- Dry Ice

Target Details

  • Target: cMyc protooncogene (Myc) fused with estragen receptor (ER).

Related Tools

  • Related tools: Anti-cMyc [9E10] ; Anti-cMyc [9E11]