Gulf War Illness Rat

Repeated low-dose organophosphate diisopropyl fluorophosphate (DFP) exposre leads to the development of depression and cognitive impairment in a rat model of Gulf War Illness

Contributors

Inventor Institute
Laxmikant Deshpande Virginia Commonwealth University
Cat. #: 154268
Target: acetylcholinesterase
Disease: Gulf War Illness
Zygosity: unknown
Phenotype: Gulf War Illness
Product description: Repeated low-dose organophosphate diisopropyl fluorophosphate (DFP) exposre leads to the development of depression and cognitive impairment in a rat model of Gulf War Illness
Production details: Rats were injected s.c. with 400 Âľg/kg DFP once-daily for 5 days
Additional notes: Male Sprague-Dawley Rats
References:

Phillips et al. 2019. Toxicol Sci. 169(2):567-578. PMID: 30859209.

Targeting Intracellular Calcium Stores Alleviates Neurological Morbidities in a DFP-Based Rat Model of Gulf War Illness.

Phillips et al. 2018. Mil Med. 183(suppl_1):552-555. PMID: 29635560.

Chronic Neurological Morbidities and Elevated Hippocampal Calcium Levels in a DFP-Based Rat Model of Gulf War Illness.

Phillips et al. 2016. Neurotoxicology. 52:127-33. PMID: 26619911.

Repeated low-dose organophosphate DFP exposure leads to the development of depression and cognitive impairment in a rat model of Gulf War Illness.

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