TOV-21G cell line

Spontaneously immortalised ovarian clear cell carcinoma cell line used in drug-response and compound-screening studies.

Contributors

Inventor Institute
Anne-Marie Mes-Masson and Diane Provencher Centre Hospitalier de L’université de Montréal
SKU: 161764
Product description: TOV-21G is an ovarian clear cell carcinoma cell line derived from a primary stage III, grade 3 tumour before chemotherapy. The line is widely used as a model of ovarian clear cell carcinoma and has been reported to carry alterations affecting ARID1A and PIK3CA, with loss of ARID1A protein expression and activation of PI3K/AKT signalling demonstrated in later studies. These molecular features make TOV-21G useful for investigating clear cell ovarian cancer biology, including ARID1A/PI3K-associated pathways, and for testing whether findings observed in other ovarian cancer models extend to a distinct histotype.
Alternate name: TOV-21G
Gender: Female
CRISPR: No
Cellosaurus ID: CVCL_3613
Receptors of note: No
Related tools: 161766 ; 161765
Cat. #: 161764
Cancer types: Ovarian cancer
Research Fields: Cancer
Organism: Human
Tissue: Derived from solid tumors of ovarian cancer patient
Gender: Female
Primary citation: Provencher et al. 2000. In Vitro Cell.Dev.Biol.-Animal (36): 357–361. PMID:10949993
Shipping conditions: Dry Ice
Growth medium: OSE medium consisting of 50:50 medium 199:105 (Sigma), with 2.5 μg/mL amphotericin B and 50 μg/mL gentamicin
Subculture routine: Split confluent cultures 1:3, using 0.25% trypsin or trypsin/EDTA, 5% CO2, 37°C
Temperature: 37.0°C
Atmosphere: Normal oxygen, 5 % CO2
References:

Raspaglio et al. 2023. Cancers (Basel). 18,15(8):2361. PMID: 37190289

Yee et al. 2022. Front Bioeng Biotechnol. 10,10:836984. PMID: 35223797

Brodeur et al. 2021. Sci Rep. 14,11(1):18183. PMID: 34521878

Buttarelli et al. 2022. J Exp Clin Cancer Res. 4,41(1):50. PMID: 35120576

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