TOV-112D cell line

Ovarian carcinoma cell line originally described as endometrioid, with later pathology reassessment supporting classification as dedifferentiated ovarian carcinoma

Contributors

Inventor Institute
Anne-Marie Mes-Masson and Diane Provencher Centre Hospitalier de L’université de Montréal
SKU: 161766
Product description: TOV-112D is an ovarian carcinoma cell line originally established from a stage IIIC, grade 3 tumour and historically described as endometrioid carcinoma. In the 2021 study Re-assigning the histologic identities of COV434 and TOV-112D ovarian cancer cell lines, the original tumour pathology was re-reviewed and TOV-112D was reclassified as a dedifferentiated ovarian carcinoma based on morphological, immunohistochemical and clinical features. The study showed differentiated and undifferentiated regions in the original tumour and reported loss of SMARCA4 and SMARCA2 protein in TOV-112D cells; re-expression of SMARCA4 markedly suppressed cell growth. These findings support the use of TOV-112D as a model for studying dedifferentiated ovarian carcinoma and SWI/SNF-associated tumour biology, while acknowledging its historical classification as an endometrioid ovarian cancer model.
Alternate name: TOV-112D
Gender: Female
CRISPR: No
Receptors of note: No
Related tools: 161764 ; 161765
Cat. #: 161766
Cancer types: Ovarian cancer
Research Fields: Cancer
Organism: Human
Tissue: Derived from solid tumors of ovarian cancer patient
Gender: Female
Morphology: Able to form compact spheroids
Primary citation: Provencher et al. 2000. In Vitro Cell.Dev.Biol.-Animal (36): 357–361. PMID:10949995
References:

Raspaglio et al. 2023. Cancers (Basel). 18

15(8):2361. PMID: 37190289 Yee et al. 2022. Front Bioeng Biotechnol. 10

10:836984. PMID: 35223797 Brodeur et al. 2021. Sci Rep. 14

11(1):18183. PMID: 34521878 Buttarelli et al. 2022. J Exp Clin Cancer Res. 4

41(1):50. PMID: 35120576

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