Cat. #162300
SiHa IFITM1+IFITM3 KO
Cat. #: 162300
Organism: Human
Tissue: Uterus
Disease: Cancer
Model: Transgenic (KO)
£575.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Marta Nekulová
Institute: Masaryk Memorial Cancer Institute
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: SiHa IFITM1+IFITM3 KO
- Parental cell: SiHa
- Organism: Human
- Gender: Female
- Tissue: Uterus
- Donor: 55 years old, Japanese
- Disease: Cancer
- Morphology: Epithelial
- Growth properties: Adherent
- Model: Transgenic (KO)
- Model description: CRISPR Cas9 abolished expression of Interferon Induced Transmembrane Protein 1 (IFITM1) and Interferon Induced Transmembrane Protein 3 (IFITM3)
- Crispr: Yes
- Description: SiHa cell line with CRISPR Cas9 abolished expression of Interferon Induced Transmembrane Protein 1 (IFITM1) and 3 (IFITM3)
- Application: Cell culture
Target Details
- Target: Interferon Induced Transmembrane Protein 1 (IFITM1), Interferon-induced transmembrane protein 3 (IFITM3)
- Target background: Interferon Induced Transmembrane Protein 1 (IFITM1) and Interferon-induced transmembrane protein 3 (IFITM3) are antiviral proteins which inhibit the entry of different viral components into the host cell cytoplasm. IFITM1 is also involved in the progression of laryngeal squamous carcinoma and in the distant metastasis of small-cell lung cancer. Interferon-induced transmembrane protein 3 (IFITM3) prevents the viral infection of the cell by modulating the local lipid
Applications
- Application: Cell culture
Handling
- Format: Frozen
- Growth medium: RPMI 1640 medium supplemented with 10% (v/v) fetal bovine serum and 1% penicillin/streptomycin
- Atmosphere: 5% CO2
- Storage conditions: Liquid Nitrogen
- Cultured in antibiotics: yes, 1% penicillin/streptomycin
Related Tools
- Related tools: SiHa IFITM1 KO, SiHa IFITM3 KO
