#157675

RMA-S.Trh4 cells

Cat. #157675

RMA-S.Trh4 cells

Cat. #: 157675

Sub-type: Continuous

Unit size: 1x10^6 cells / vial

Availability: 8-10 weeks

Organism: Mouse

Tissue: Lymphatic Tissue

Disease: Cancer

Model: Tumour line

£575.00

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: Thorbald Van Hall

Institute: Leiden University and Leiden University Medical Center; Stichting Oncode Institute

Tool Details
Target Details
Handling
References

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

  • Name: RMA-S.Trh4 cells
  • Cancer: Blood cancer
  • Cancers detailed: Mouse Leukemia
  • Research fields: Cancer
  • Tool sub type: Continuous
  • Parental cell: RMA-S
  • Organism: Mouse
  • Tissue: Lymphatic Tissue
  • Disease: Cancer
  • Model: Tumour line
  • Description: This cell line provides a model to help to understand T-cell recognition through Trh4 expression. ER-resident ceramide synthase Trh4 is a prototypic example of a neo-antigen selectively presented by cells through various pathways. RMA-S lymphoma cells are TAP-deficient on account of an incomplete TAP2 chain, whereas RMA cells have their TAP chain intact.The Trh4 peptide is only presented on cells with impaired TAP function through the classical MHC I pathway. This cell line presents said Trh4...
  • Production details: Retroviral transduction of the mouse Trh4 gene in an IRES-GFP construct
  • Biosafety level: 1
  • Recommended controls: RMA.Trh4 cells
  • Cellosaurus id: CVCL_2180

Target Details

  • Target: Trh4

Handling

  • Format: Frozen
  • Unit size: 1x10^6 cells / vial
  • Shipping conditions: Dry ice
  • Storage conditions: Liquid Nitrogen
  • Mycoplasma free: Yes

References

  • Oliveira et al. 2011. Eur J Immunol. 41(11):3114-24. PMID: 21898382.