PEO23 Cell Line

A patient-derived serous ovarian cancer cell line, reported as a post-treatment platinum-resistant counterpart to PEO14, and used to study drug resistance and disease heterogeneity. Exlcusive to CancerTools. Save 30% on this cell line this summer. Use code SUM26CELL at checkout.

Contributors

Inventor Institute
Simon Langdon Cancer Research UK Edinburgh Centre
SKU: 151677
Product description: PEO23 was collected on relapse after cisplatin and chlorambucil treatment. PEO23 exhibits poor growth in semi-solid medium (agar). PEO23 is from the same patient asTO14 cell lines.
Alternate name: peo23; PE023; PEO-23
Gender: Female
Conditional: Yes
Additional notes: PEO23 is one of nine cell lines from the PE ovarian adenocarcinoma panel, which was derived from four patients at different stages of ovarian cancer, from various malignant sites and at various treatment stages. The wider panel has been used as a model system for research into mechanisms of oestrogen action in ovarian adenocarcinoma tumour cells and for studies of oestrogen agonist/antagonist efficacy and toxicity. PEO23 has been reported to show poor growth in semi-solid medium, including agar. PEO23 is also related to TO14, a solid-metastasis-derived line from the same patient.
Cellosaurus ID: CVCL_2689
Disease: Cancer
Cat. #: 151677
Provenance and Ownership: The PEO23 Cell Line is owned by Cancer Research UK. CancerTools supplies the PEO23 Cell Line under licence from Cancer Research UK and is the authorised source for its distribution. Sourcing PEO23 Cell Line directly from the IP owner ensures authenticity, provenance and compliance with all applicable licensing and research use requirements.
Unit size: 1×10^6 cells / vial
Cancer types: Ovarian cancer
Research Fields: Cancer; Drug development
Organism: Human
Tissue: Ovary
Gender: Female
Model: Tumour line
Growth properties: Adherent
Cancer Types In Detail: Adenocarcinoma
Format: Frozen
Shipping conditions: Dry ice
Growth medium: RPMI-1640 + 2mM Glutamine + 2mM Sodium Pyruvate + 10% Foetal Bovine Serum.
Subculture routine: Split sub-confluent cultures (70-80%) 1:4 to 1:10 seeding at 2- 3 x 10^4 cells/cm² using 0.05% trypsin or trypsin/EDTA; 5% CO₂; 37°C. Doubling time approximately 120 hours.
References:

Langdon et al. 1990. Br J Cancer. 62(2):213-216. PMID: 2386737.

Langdon et al. 1988. Cancer Res. 48(21):6166-72. PMID: 3167863

Images

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PEO23 Cell Line. Image courtesy of the European Collection of Authenticated Cell Cultures (ECACC)

Citations And Reviews

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