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#162296

MDA-MB-468 TAp63 alpha TET-ON cell line

Cat. #162296

MDA-MB-468 TAp63 alpha TET-ON cell line

Cat. #: 162296

Organism: Human

Tissue: Pleural effusion of metastatic adenocarcinoma of the breast

Disease: Cancer

Model: Transgenic

£575.00

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Contributor

Inventor: Marta Nekulová

Institute: Masaryk Memorial Cancer Institute

Primary Citation: Nekulova et al. (2016). BMC Cancer, 10;16(1):782, PMID: 27724925

Tool Details
Target Details
Applications
Handling
Related Tools
References

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

  • Name: MDA-MB-468 TAp63 alpha TET-ON cell line
  • Alternate name: MDA-MB-468 pcDNA6/TR pT-REX-DEST30-TAp63 alpha
  • Parental cell: MDA-MB-468
  • Organism: Human
  • Gender: Female
  • Tissue: Pleural effusion of metastatic adenocarcinoma of the breast
  • Donor: 51 years old, black
  • Disease: Cancer
  • Morphology: Epithelial
  • Growth properties: Adherent
  • Model: Transgenic
  • Model description: Conditional expression of TAp63? isoform of p63 protein after induction with tetracycline
  • Conditional: Yes
  • Conditional description: the TAp63? isoform of p63 protein is conditionally expressed after induction with tetracycline
  • Description: MDA-MB-468 cell line expressing the TAp63? isoform of p63 protein after induction with tetracycline
  • Application: Cell culture

Target Details

  • Target: p63, isoform TAp63?
  • Target background: TAp63? is a p63 isoform with oncogenic properties in epithelial cancers. TAp63? has multiple roles, such as inducing apoptosis or promoting cancer stem cells

Applications

  • Application: Cell culture

Handling

  • Format: Frozen
  • Atmosphere: humidified CO2 atmosphere
  • Storage conditions: Liquid Nitrogen
  • Cultured in antibiotics: yes, penicillin/streptomycin

Related Tools

  • Related tools: MDA-MB-468 delta Np63 alpha TET-ON (MDA-MB-468 pcDNA6/TR pT-REX-DEST30-delta Np63 alpha), MDA-MB-468 TET-ON (MDA-MB-468 pcDNA6/TR)

References

  • Holcakova et al. (2017). Breast Cancer Res Treat. 163(3):475-484, PMID: 28349272
  • Nekulova et al. (2016). BMC Cancer, 10
  • 16(1):782, PMID: 27724925

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