Monoclonal antibody anti-GSK-3 (GSK-4G)

Antibody to glycogen synthase kinase 3, a serine/threonine kinase involved in numerous signaling pathways, including those related to cell proliferation and survival in cancer. The peptide used as immunogen derives from a region of the catalytic domain (between sub-domain VII and VIII) of the Drosophila GSK-3 /shaggy enzyme. Because of the extremely high conservation of […]

Contributors

Institute
Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC)
Cat. #: 162406
Research Fields: Cell signaling and signal transduction
Application: WB, IHC, weak in immunoprecipitation
Target: GSK-3 / Shaggy protein kinase family
Reactivity: Drosophila, should also cross react with all species homologues. Cross-reacts effectively with rat, Sch. Pombe, Dictyostelium
Clone: 4G-1E
Host: Mouse
Class: Monoclonal
Primary citation: Harwood et al., Cell (1995) 80 139-148. PMID: 7813009
Product description: Antibody to glycogen synthase kinase 3, a serine/threonine kinase involved in numerous signaling pathways, including those related to cell proliferation and survival in cancer. The peptide used as immunogen derives from a region of the catalytic domain (between sub-domain VII and VIII) of the Drosophila GSK-3 /shaggy enzyme. Because of the extremely high conservation of this region among the known enzymes of many different species clone 4G-1E, which recognizes the Drosophila enzyme, should cross react with all species homologues (cross-reacts effectively with rat, Sch. Pombe, Dictyostelium*).
Additional notes: Avoid repeat freezing and thawing cycles. Does not contain any preservative.
Conjugation: Unconjugated
Isotype: IgG1, K
Immunogen: Synthetic peptide coupled to ovalbumin : (C)K203 QLLHGEPNVSYICSRY219
Target background: Glycogen synthase kinase 3 is a serine/threonine kinase involved in numerous signaling pathways, including those related to cell proliferation and survival in cancer.
Storage conditions: -20°C (up to 3 years)
References:

Harwood et al., Cell (1995) 80 139-148, PMID: 7813009

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