This antibody is not reactive with goblet cells; thus 4B7/1 can be used as a marker for brush border cells.
| Inventor | Institute |
|---|---|
| Cecile Wright-Crosnier ; Julian Lewis ; Linda Ariza-McNaughton ; Neil Vargesson | Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| Cat. #: | 151511 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Cancer types: | Digestive / Gastrointestinal cancer |
| Research Fields: | Cell biology;Cell signaling and signal transduction;Developmental biology;Genetics;Stem cell biology;Tags and cell markers |
| Application: | IHC ; IF ; IP ; WB |
| Target: | Zebrafish gut absorptive cell epitopes |
| Reactivity: | Zebrafish |
| Clone: | FIS 4B7/1 |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | This antibody is not reactive with goblet cells; thus 4B7/1 can be used as a marker for brush border cells. |
|---|---|
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Immunogen: | Zebrafish intestine |
| Myeloma used: | Sp2/0-Ag14 |
| Target background: | The transparency of the juvenile zebrafish and its genetic advantages make it an attractive model for the study of intestinal differentiation and renewal. This antibody labels the brush border / glycocalyx of intestinal absorptive cells (apical ends of microvilli). |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Matthews et al. 2008. Dev Dyn. 237(1):124-31. PMID: 18095340. Transcription factor onecut3 regulates intrahepatic biliary development in zebrafish. Dong et al. 2007. Nat Genet. 39(3):397-402. PMID: 17259985. Fgf10 regulates hepatopancreatic ductal system patterning and differentiation. Bates et al. 2006. Dev Biol. 297(2):374-86. PMID: 16781702. Distinct signals from the microbiota promote different aspects of zebrafish gut differentiation. Crosnier et al. 2005. Development. 132(5):1093-104. PMID: 15689380. Delta-Notch signalling controls commitment to a secretory fate in the zebrafish intestine. |
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