Nucleotide excision repair (NER) is a DNA repair pathway that removes lesions induced by a variety of agents such as UV irradiation. ERCC1 and XPF form the heterodimer ERCC1-XPF, forming a DNA endonuclease that is essential for the dual incision step of NER (cleaves 5′ of the DNA lesion).
| Institute |
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| Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| Cat. #: | 151521 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Genetics |
| Application: | ELISA ; IHC ; IF ; WB |
| Target: | XPF |
| Reactivity: | Human |
| Clone: | XPF 3F2/3 |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | Nucleotide excision repair (NER) is a DNA repair pathway that removes lesions induced by a variety of agents such as UV irradiation. ERCC1 and XPF form the heterodimer ERCC1-XPF, forming a DNA endonuclease that is essential for the dual incision step of NER (cleaves 5' of the DNA lesion). |
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| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Immunogen: | A recombinant His-tagged fragment of human XPF protein produced in E. coli |
| Myeloma used: | Sp2/0-Ag14 |
| Target background: | Nucleotide excision repair (NER) is a DNA repair pathway that removes lesions induced by a variety of agents such as UV irradiation. ERCC1 and XPF form the heterodimer ERCC1-XPF, forming a DNA endonuclease that is essential for the dual incision step of NER (cleaves 5' of the DNA lesion). |
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| Format: | Liquid |
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| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Facista et al. 2012. Genome Integr. 3(1):3. PMID: 22494821. Deficient expression of DNA repair enzymes in early progression to sporadic colon cancer. Bhagwat et al. 2009. Cancer Res. 69(17):6831-8. PMID: 19723666. Immunodetection of DNA repair endonuclease ERCC1-XPF in human tissue. |
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