VHL is Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex
| Inventor | Institute |
|---|---|
| Keith Willison | The Institute of Cancer Research |
| Cat. #: | 153442 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer;Cell biology;Genetics;Metabolism |
| Target: | VHL |
| Clone: | LIZ/1/67c |
| Class: | Monoclonal |
| Alternate name: | von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase |
|---|---|
| Product description: | VHL is Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. It seems to act as target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. It is involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. |
| Conjugation: | Unconjugated |
| Target background: | VHL is Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. It seems to act as target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. It is involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
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