Anti-TTP

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

• Name: Anti-TTP
• Alternate name: TTP, ZFP36 Ring Finger Protein, Growth Factor-Inducible Nuclear Protein NUP475 G/G1 Switch Regulatory Protein 24, RNF162A, Zfp-36, NUP475, GS24, TIS11
• Cancer: Blood cancer
• Cancers detailed: Bone Marrow
• Research fields: Cell signaling and signal transduction;Genetics;Immunology
• Tool sub type: Primary antibody
• Class: Polyclonal
• Purpose: Marker
• Conjugation: Unconjugated
• Molecular weight: 36 kDa
• Reactivity: Human ; Mouse
• Host: Rabbit
• Application: IP ; WB
• Description: Members of the tristetraprolin (TTP) family of RNA binding proteins can bind to adenine/uridine-rich elements (AREs) in the 3’-untranslated regions (3’UTRs) of specific mRNAs, and then promote their turnover. For example, TTP is a component of a negative feedback loop that interferes with TNF-alpha production by destabilizing its mRNA. TTP has been shown to interact with 14-3-3 protein family members, such as YWHAH, and with NUP214, a member of the nuclear pore complex. Mice deficient in TTP develop a complex syndrome of inflammatory diseases.
• Immunogen: 34 C-terminal amino acids of TTP fused to GST

Target Details

• Target: Tristetraprolin
• Molecular weight: 36 kDa
• Tissue cell line specificity: Rabbit
• Target background: Members of the tristetraprolin (TTP) family of RNA binding proteins can bind to adenine/uridine-rich elements (AREs) in the 3'-untranslated regions (3'UTRs) of specific mRNAs, and then promote their turnover. For example, TTP is a component of a negative feedback loop that interferes with TNF-alpha production by destabilizing its mRNA. TTP has been shown to interact with 14-3-3 protein family members, such as YWHAH, and with NUP214, a member of the nuclear pore complex. Mice deficient in TTP ...

Applications

• Application: IP ; WB

Handling

• Format: Liquid
• Concentration: 0.9-1.1 mg/ml
• Unit size: 100 ug
• Storage conditions: -15° C to -25° C
• Shipping conditions: Shipping at 4° C

References

• Sedlyarov et al. 2016. Mol Syst Biol. 12(5):868. PMID: 27178967.
• Tristetraprolin binding site atlas in the macrophage transcriptome reveals a switch for inflammationresolution.
• Kratochvill et al. 2011. Mol Syst Biol. 7:560. PMID: 22186734.
• Tristetraprolin-driven regulatory circuit controls quality and timing of mRNA decay in inflammation.
• Schaljo et al. 2009. J Immunol. 183(2):1197-206. PMID: 19542371.
• Tristetraprolin is required for full anti-inflammatory response of murine macroph...