Monoclonal antibody targeting TIAM1
| Inventor | Institute |
|---|---|
| Jihong Bai, PhD | Fred Hutchinson Cancer Center |
| Cat. #: | 161719 |
|---|---|
| Tool sub type: | Primary antibody |
| Application: | WB(1:1000), IP |
| Target: | TIAM1 |
| Reactivity: | human; mouse; rat |
| Clone: | 4E7-b1 |
| Host: | mouse |
| Class: | Monoclonal |
| Product description: | T-lymphoma invasion and metastasis-inducing protein 1 (TIAM1) is a protein coding gene, specifically for RAC-1. RAC-1 is a specific guanine nucleotide exchange factor (GEF). GEFs mediate the exchange of guanosine diphosphate (GDP) for guanosine triphosphate (GTP). This gene thus regulates RAC1 signaling pathways that affect cell shape, migration, adhesion, growth, survival, and polarity, as well as influencing actin cytoskeletal formation, endocytosis, and membrane trafficking. Diseases associated with TIAM1 include lymphoma and Wolf-Hirschhorn Syndrome. |
|---|---|
| Conjugation: | No |
| Molecular weight: | 178 kDa |
| Immunogen: | Recombinant TIAM1 GEF domain (mouse 1029-1418) |
| Target background: | recombinant T-lymphoma invasion and metasis-inducing protein 1 (TIAM1) |
|---|
| Storage buffer: | PBS with 0.02% azide |
|---|---|
| Storage conditions: | '-15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
No publication, validated internally |
|---|
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