Anti-TIAM1 [4E7-b1]

Monoclonal antibody targeting TIAM1

Contributors

Inventor Institute
Jihong Bai, PhD Fred Hutchinson Cancer Center
Cat. #: 161719
Tool sub type: Primary antibody
Application: WB(1:1000), IP
Target: TIAM1
Reactivity: human; mouse; rat
Clone: 4E7-b1
Host: mouse
Class: Monoclonal
Product description: T-lymphoma invasion and metastasis-inducing protein 1 (TIAM1) is a protein coding gene, specifically for RAC-1. RAC-1 is a specific guanine nucleotide exchange factor (GEF). GEFs mediate the exchange of guanosine diphosphate (GDP) for guanosine triphosphate (GTP). This gene thus regulates RAC1 signaling pathways that affect cell shape, migration, adhesion, growth, survival, and polarity, as well as influencing actin cytoskeletal formation, endocytosis, and membrane trafficking. Diseases associated with TIAM1 include lymphoma and Wolf-Hirschhorn Syndrome.
Conjugation: No
Molecular weight: 178 kDa
Immunogen: Recombinant TIAM1 GEF domain (mouse 1029-1418)
Target background: recombinant T-lymphoma invasion and metasis-inducing protein 1 (TIAM1)
Storage buffer: PBS with 0.02% azide
Storage conditions: '-15° C to -25° C
Shipping conditions: Dry ice
References:

No publication, validated internally

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