Monoclonal antibody used in study of TDP-43 associated diseases.
| Inventor | Institute |
|---|---|
| Fiona Benson | Lancaster University |
| Cat. #: | 152054 |
|---|---|
| Unit size: | 100 ug |
| Research Fields: | Genetics;Microbiology;Neurobiology |
| Application: | ELISA ; WB |
| Target: | TDP43 |
| Reactivity: | Human |
| Clone: | DB9 |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | Monoclonal antibody used in study of TDP-43 associated diseases. Background and Research Application TAR DNA-binding protein 43 (TDP-43) belongs to the hnRNP protein family and plays an important role in transcription, pre-mRNA splicing, mRNA stability and mRNA transport. It is involved in splicing of the apolipoprotein A-II and cystic fibrosis transmembrane gene. This protein is highly expressed in the pancreas, placenta, lung, genital tract and spleen. Mutations in TDP-43 have been associated with amyotrophic lateral sclerosis, frontotemporal dementia, Parkinson's disease and Alzheimer's disease. |
|---|---|
| Conjugation: | Unconjugated |
| Isotype: | IgG1 kappa |
| Immunogen: | A his-tagged recombinant protein corresponding to amino acid residues 208-414 of human TDP-43. |
| Immunogen Uniprot ID: | Q13148 |
| Myeloma used: | Sp2/0-Ag14 |
| Target background: | Monoclonal antibody used in study of TDP-43 associated diseases. Background and Research Application TAR DNA-binding protein 43 (TDP-43) belongs to the hnRNP protein family and plays an important role in transcription, pre-mRNA splicing, mRNA stability and mRNA transport. It is involved in splicing of the apolipoprotein A-II and cystic fibrosis transmembrane gene. This protein is highly expressed in the pancreas, placenta, lung, genital tract and spleen. Mutations in TDP-43 have been associated with amyotrophic lateral sclerosis, frontotemporal dementia, Parkinson's disease and Alzheimer's disease. |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
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