Anti-SIGLEC3 [CD33 3D6]

CD33 is also expressed on, and a useful marker for, peripheral monocytes. CD33 is also useful for distinguishing myelogenous leukaemia cells from lymphoid or erythroid leukaemias.

Contributors

Inventor Institute
Paul Crocker University of Oxford
Cat. #: 151219
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Cancer;Cell biology;Immunology;Stem cell biology
Application: ELISA
Target: SIGLEC3 (CD33)
Reactivity: Human
Clone: CD33 3D6
Host: Mouse
Class: Monoclonal
Alternate name: Sialic Acid Binding Ig Like Lectin 12; SIGLECL1; SLG 3; Siglec-12; Siglec-L1; S2V
Product description: The siglecs are a family of membrane bound lectins (of the immunoglobulin superfamily) that bind sialic acid and mediate cell-cell interactions. Family members include sialoadhesin, CD22 and CD33. CD33 is found on granulocyte and macrophage precursors in the bone marrow, but not on pluripotent stem cells. CD33 is also expressed on, and a useful marker for, peripheral monocytes. CD33 is also useful for distinguishing myelogenous leukaemia cells from lymphoid or erythroid leukaemias.
Conjugation: Unconjugated
Isotype: IgG1
Immunogen: CD33-Fc recombinant protein
Myeloma used: Sp2/0-Ag14
Target background: The siglecs are a family of membrane bound lectins (of the immunoglobulin superfamily) that bind sialic acid and mediate cell-cell interactions. Family members include sialoadhesin, CD22 and CD33. CD33 is found on granulocyte and macrophage precursors in the bone marrow, but not on pluripotent stem cells. CD33 is also expressed on, and a useful marker for, peripheral monocytes. CD33 is also useful for distinguishing myelogenous leukaemia cells from lymphoid or erythroid leukaemias.
Format: Liquid
Concentration: 1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice
References:

Taylor et al. 1999. J Biol Chem. 274(17):11505-12. PMID: 10206955.

The myeloid-specific sialic acid-binding receptor, CD33, associates with the protein-tyrosine phosphatases, SHP-1 and SHP-2.

Freeman et al. 1995. Blood. 85(8):2005-12. PMID: 7718872.

Characterization of CD33 as a new member of the sialoadhesin family of cellular interaction molecules.

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