Anti-RAX/PACT [HL1950]

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

• Name: Anti-RAX/PACT [HL1950]
• Alternate name: RAX/PACT; PRKRA
• Research fields: Cell signaling and signal transduction
• Tool sub type: Primary antibody
• Class: Monoclonal
• Conjugation: Unconjugated
• Reactivity: Human ; Rat ; Mouse
• Host: Mouse
• Application: ELISA ; WB ; IHC
• Description: Rax (mouse protein) and PACT (human ortholog) are the only known activators of PKR (double-stranded RNA dependent kinase). Rax and PACT share 98% amino acid sequence homology and contain three conserved dsRNA binding motifs. Phosphorylation of Serine 18 of RAX is required for PKR activation, which is known to be involved in the host anti-viral response, and can act as a signaling mediator by cytokines, growth factors and even tumor supressors.
• Immunogen: Two synthetic peptides corresponded to amino acids 13-25, containing phosphorylated and non-phosphorylated Ser 18 of PACT of mouse origin
• Isotype: IgG2b kappa

Target Details

• Target: interferon-inducible double strane RNA-dependent protein kinease/Protein activator of the interferon-induced protein kinase (Rax/PACT)
• Target background: Rax (mouse protein) and PACT (human ortholog) are the only known activators of PKR (double-stranded RNA dependent kinase). Rax and PACT share 98% amino acid sequence homology and contain three conserved dsRNA binding motifs. Phosphorylation of Serine 18 of RAX is required for PKR activation, which is known to be involved in the host anti-viral response, and can act as a signaling mediator by cytokines, growth factors and even tumor supressors.

Applications

• Application: ELISA ; WB ; IHC

Handling

• Format: Liquid
• Unit size: 100 ug
• Shipping conditions: Shipping at 4° C

References

• Bennett et al. 2004. J Biol Chem. 279(41):42687-93. PMID: 15299031.