Anti-ORF45 [ORF45]

This anti-ORF45 has been shown to purify different populations of ORF45 as well as enable the targeted depletion or enrichment of subpopulations of ORF45. This anti-ORF45 was generated using a baculovirus-synthesized ORF45 as an antigen.

Contributors

Inventor Institute
Fanxiu Zhu Florida State University Research Foundation
Cat. #: 160637
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Genetics;Microbiology
Application: IP ; WB
Target: Open Reading Frame 45
Reactivity: Other Species
Host: Mouse
Class: Monoclonal
Product description: Kaposi's sarcoma-associated herpesvirus (KSHV) has been identified as the causative agent of Kaposi's sarcoma, the most common malignancy in HIV-infected individuals. KSHV has also been shown to be be associated with two lymphoproliferative diseases (Fu et al., 2015). ORF45 (tegument) is a gene associated with the lytic viral life cycle of KSHV and has been shown to have multiple functions throughout the viral life cycle. ORF45 is a crucial component of progeny virion production in conjunction with ORF33. ORF45 binds to and stabilizes ORF33. This anti-ORF45 has been shown to purify different populations of ORF45 as well as enable the targeted depletion or enrichment of subpopulations of ORF45. This anti-ORF45 was generated using a baculovirus-synthesized ORF45 as an antigen.
Conjugation: Unconjugated
Isotype: IgG
Immunogen: A baculovirus-synthesized ORF45 protein was used as an antigen
Target background: Kaposi's sarcoma-associated herpesvirus (KSHV) has been identified as the causative agent of Kaposi's sarcoma, the most common malignancy in HIV-infected individuals. KSHV has also been shown to be be associated with two lymphoproliferative diseases (Fu et al., 2015). ORF45 (tegument) is a gene associated with the lytic viral life cycle of KSHV and has been shown to have multiple functions throughout the viral life cycle. ORF45 is a crucial component of progeny virion production in conjunction with ORF33. ORF45 binds to and stabilizes ORF33. This anti-ORF45 has been shown to purify different populations of ORF45 as well as enable the targeted depletion or enrichment of subpopulations of ORF45. This anti-ORF45 was generated using a baculovirus-synthesized ORF45 as an antigen.
Format: Liquid
Shipping conditions: Dry ice
References:

Wu et al. 2016. J Virol. 90(4):1741-56. PMID: 26637455.

Gillen et al. 2015. J Virol. 89(9):4918-31. PMID: 25694600.

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