Cat. #160639
Anti-ORF38 [ORF38]
Cat. #: 160639
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 10-12 weeks
Target: Open Reading Frame 38
Class: Monoclonal
Application: IP
Reactivity: Other Species
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Fanxiu Zhu
Institute: Florida State University Research Foundation
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-ORF38 [ORF38]
- Research fields: Genetics;Microbiology
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Reactivity: Other Species
- Host: Mouse
- Application: IP
- Description: Kaposi's sarcoma-associated herpesvirus (KSHV) has been identified as the causative agent of Kaposi's sarcoma, the most common malignancy in HIV-infected individuals. KSHV has also been shown to be be associated with two lymphoproliferative diseases (Fu et al., 2015). Open reading frame 38 (ORF38) (tegument) is a gene associated with the late lytic viral life cycle of KSHV. This anti-ORF38 (tegument) was generated using a baculovirus-synthesized ORF38 as an antigen. ORF38 has been shown to be a critical binding partner for ORF33. The interaction of ORF33 and ORF38 plays an important role in the transport of newly assembled viral particles through vesicles. ORF38 has been shown experimentally to be an abundant tegument protein and a critical virion component. Conserved interaction between ORF33 and ORF38 homologues plays critical roles in the production of progeny virions but are not essential for viral gene expression.
- Immunogen: A baculovirus-synthesized ORF38 was used as an antigen
- Isotype: IgG
Target Details
- Target: Open Reading Frame 38
- Target background: Kaposi's sarcoma-associated herpesvirus (KSHV) has been identified as the causative agent of Kaposi's sarcoma, the most common malignancy in HIV-infected individuals. KSHV has also been shown to be be associated with two lymphoproliferative diseases (Fu et al., 2015).Open reading frame 38 (ORF38) (tegument) is a gene associated with the late lytic viral life cycle of KSHV. This anti-ORF38 (tegument) was generated using a baculovirus-synthesized ORF38 as an antigen. ORF38 has been shown to be a critical binding partner for ORF33. The interaction of ORF33 and ORF38 plays an important role in the transport of newly assembled viral particles through vesicles. ORF38 has been shown experimentally to be an abundant tegument protein and a critical virion component. Conserved interaction between ORF33 and ORF38 homologues plays critical roles in the production of progeny virions but are not essential for viral gene expression.
Applications
- Application: IP
Handling
- Format: Liquid
- Unit size: 100 ug
- Shipping conditions: Shipping at 4° C
References
- Wu et al. 2016. J Virol. 90(4):1741-56. PMID: 26637455.
- Gillen et al. 2015. J Virol. 89(9):4918-31. PMID: 25694600.
